ArticleFrontiers in immunology2017
The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01640275 (The Effect of Isoflurane Versus Propofol Anesthesia on Alzheimers Disease CSF Markers), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Isoflurane Versus Propofol Anesthesia on Alzheimers Disease CSF Markers
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium.Applied neuropsychology. AdultTrial
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025Article
- Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS).Critical care medicine · 2025Article
- Middle aged CAMKII-Cre:CbsExperimental animals · 2024Article
- Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- MiR-128-3p Attenuates the Neurotoxicity in Rats Induced by Isoflurane Anesthesia.Neurotoxicity research · 2022Article
- Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial.Frontiers in psychiatry · 2022Article
- Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.British journal of anaesthesia · 2021Article
- Cardiac Arrest Induced by Asphyxia Versus Ventricular Fibrillation Elicits Comparable Early Changes in Cytokine Levels in the Rat Brain, Heart, and Serum.Journal of the American Heart Association · 2021Article
- Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.Journal of Alzheimer's disease : JAD · 2021Observational
- Gene-Specific DNA Methylation Linked to Postoperative Cognitive Dysfunction in Apolipoprotein E3 and E4 Mice.Journal of Alzheimer's disease : JAD · 2021Article
- Human plasma biomarker responses to inhalational general anaesthesia without surgery.British journal of anaesthesia · 2020Article
- The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.Journal of Alzheimer's disease : JAD · 2020Article
- HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction.Journal of neuroinflammation · 2019Article
- EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production.PLoS pathogens · 2019Article
- Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting CaActa pharmacologica Sinica · 2019Article
- State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.British journal of anaesthesia · 2019Review
- The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.Journal of the American Geriatrics Society · 2019Observational
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
introductionAside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. MATERIALS AND
methodsTo examine whether propofol and isoflurane differentially modulate neuroinflammation in humans, cytokines were measured in a secondary analysis of cerebrospinal fluid (CSF) samples from patients prospectively randomized to receive anesthetic maintenance with propofol vs. isoflurane (registered with http://www.clinicaltrials.gov, identifier NCT01640275). We measured CSF levels of EGF, eotaxin, G-CSF, GM-CSF, IFN-α2, IL-1RA, IL-6, IL-7, IL-8, IL-10, IP-10, MCP-1, MIP-1α, MIP-1β, and TNF-α before and 24 h after intracranial surgery in these study patients.
resultsAfter Bonferroni correction for multiple comparisons, we found significant increases from before to 24 h after surgery in G-CSF, IL-10, IL-1RA, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, and TNF-α. However, we found no difference in cytokine levels at baseline or 24 h after surgery between propofol- ( DISCUSSION: These data clarify the magnitude of neuroinflammation after intracranial surgery, and raise the possibility that a coordinated neuroinflammatory response may play a role in neural injury after surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.