Evidence map›Paper›PMID 29180949›Full record

ArticleAdvanced functional materials2017

Electrically Oscillating Plasmonic Nanoparticles for Enhanced DNA Vaccination against Hepatitis C Virus.

Mohamed Shehata Draz, Ying-Jie Wang, Frank Fanqing Chen, Yuhong Xu, Hadi Shafiee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  8. Article
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  10. Article
  11. Advanced materials for personal thermal and moisture management of health care workers wearing PPE.Materials science & engineering. R, Reports : a review journal · 2021
    Review
  12. Recent Advances in Stimulus-Responsive Nanocarriers for Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  13. Review
  14. Review
  15. Glycan Nanostructures of Human Coronaviruses.International journal of nanomedicine · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Immunomodulatory Nanosystems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Mohamed Shehata DrazDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Faculty of Science Tanta University Tanta 31527, Egypt. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P. R. China.
Ying-Jie WangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P. R. China.
Frank Fanqing ChenLife Sciences Division, Lawrence Berkeley National Laboratory, Mailstop 977, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Yuhong XuSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Hadi ShafieeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Brigham and Women's Hospital · USFirst Affiliated Hospital Zhejiang University · CNLawrence Berkeley National Laboratory · USShanghai Jiao Tong University · CNZhejiang University · CN

Funding

Sensitive and quantitative point-of-care viral load testing on paperR01AI118502 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2016 to 2020
$2.2M
Developmental Pathways to Substance Use Across European & Asian American YouthF31AA020700 · NIAAA · UNIVERSITY OF WASHINGTON · PI LUK, JEREMY WING-HEI · 2011 to 2013
$123k
NIAAA NIH HHS F31 AA020700NIAID NIH HHS R01 AI118502
6 · The paper itself

Abstract

The promise of DNA vaccines is far-reaching. However, the development of potent immunization methods remains a key challenge for its use in clinical applications. Here, an approach for in vivo DNA vaccination by electrically activated plasmonic Au nanoparticles is reported. The electrical excitation of plasmonic nanoparticles can drive vibrational and dipole-like oscillations that are able to disrupt nearby cell membranes. In combination with their intrinsic ability to focus and magnify the electric field on the surface of cells, Au nanoparticles allow enhanced cell poration and facilitate the uptake of DNA vaccine. Mice immunized with this approach showed up to 100-fold higher gene expression compared to control treatments (without nanoparticles) and exhibited significantly increased levels of both antibody and cellular immune responses against a model hepatitis C virus DNA vaccine. This approach can be tuned to establish controlled and targeted delivery of different types of therapeutic molecules into cells and live animals as well.

Identifiers

PMID29180949
PMCPMC5701658
OpenAlexW2566066689

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.