Evidence map›Paper›PMID 29180857›Full record

SynthesisClinical interventions in aging2017

Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis.

Yunxia Jiang, Tao He, Wenshuai Deng, Peng Sun

Abstract readMeta-Analysis
In one paragraph

Synthesis in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Predictors of Bi-directional Transitions From Mild Cognitive Impairment in a Diverse Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  4. Article
  5. Correlation between theFrontiers in public health · 2024
    Article
  6. Review
  7. Article
  8. Mild cognitive impairment among rural-dwelling older adults in China: A community-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunxia Jiang *Nursing College of Qingdao University, Qingdao University.
Tao He *Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Wenshuai DengDepartment of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Peng SunDepartment of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of published case-control studies reported that the apolipoprotein E (ApoE) gene polymorphism was associated with the mild cognitive impairment (MCI). However, previous reports still remain conflicting. To estimate the association between ApoE polymorphism and MCI susceptibility, we searched the electronic databases including PubMed, Wanfang, CNKI (China National Knowledge Infrastructure), VIP, and EMBASE to retrieve all available studies. A total of 18 studies with 2,004 cases and 3,705 controls were included in this meta-analysis. The pooled analysis based on selected studies showed that statistically significant risk association was found between ApoE gene polymorphism and MCI in overall population (

Indexed as

AllelesApolipoprotein E2Asian PeopleCase-Control StudiesChinaCognitive DysfunctionEthnicityFemaleGenotypeHumansPolymorphism, GeneticApolipoprotein E2apolipoprotein Emeta-analysismild cognitive impairmentpolymorphism

Identifiers

PMID29180857
PMCPMC5691922

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.