ArticleNature communications2017
Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Re-exposure to reward re-evaluates related memories.Current biology : CB · 2026Article
- The impact of sugar diet on humidity preference, survival, and host landing in mosquitoes.Journal of medical entomology · 2025Article
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Food memory circuits regulate eating and energy balance.Current biology : CB · 2023Article
- Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory.Frontiers in behavioral neuroscience · 2022Article
- Excessive energy expenditure due to acute physical restraint disrupts Drosophila motivational feeding response.Scientific reports · 2021Article
- Confection Confusion: Interplay Between Diet, Taste, and Nutrition.Trends in endocrinology and metabolism: TEM · 2021Review
- The Panopticon-Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference.Frontiers in behavioral neuroscience · 2021Article
- Effects of Non-nutritive Sweeteners on Sweet Taste Processing and Neuroendocrine Regulation of Eating Behavior.Current nutrition reports · 2020Review
- Reward foraging task and model-based analysis reveal how fruit flies learn value of available options.PloS one · 2020Article
- Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.eLife · 2018Article
- Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila.Neural development · 2018Article
- Feeding-State-Dependent Modulation of Temperature Preference Requires Insulin Signaling in Drosophila Warm-Sensing Neurons.Current biology : CB · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-caloric artificial sweeteners (NAS) are widely used in modern human food, raising the question about their health impact. Here we have asked whether NAS consumption is a neutral experience at neural and behavioral level, or if NAS can be interpreted and remembered as negative experience. We used behavioral and imaging approaches to demonstrate that Drosophila melanogaster learn the non-caloric property of NAS through post-ingestion process. These results show that sweet taste is predictive of an energy value, and its absence leads to the formation of what we call Caloric Frustration Memory (CFM) that devalues the NAS or its caloric enantiomer. CFM formation involves activity of the associative memory brain structure, the mushroom bodies (MBs). In vivo calcium imaging of MB-input dopaminergic neurons that respond to sugar showed a reduced response to NAS after CFM formation. Altogether, these findings demonstrate that NAS are a negative experience for the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.