Evidence map›Paper›PMID 29180766›Full record

ArticleNature communications2017

Oscillatory brain activity in spontaneous and induced sleep stages in flies.

Melvyn H W Yap, Martyna J Grabowska, Chelsie Rohrscheib, Rhiannon Jeans, Michael Troup, Angelique C Paulk, Bart van Alphen, Paul J Shaw, Bruno van Swinderen

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 150 citations in OpenAlex.

  1. Trial
  2. Article
  3. Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  4. Article
  5. A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026
    Article
  6. Article
  7. Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Current Evidence for Sleep States inCurrent sleep medicine reports · 2026
    Review
  10. The use ofFrontiers in cell and developmental biology · 2026
    Review
  11. Multicolor photoreactions of the red light-activated channelrhodopsin Chrimson.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025
    Article
  13. Recognition of distinct sleep states inbioRxiv : the preprint server for biology · 2025
    Article
  14. The exploration of consciousness in insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  15. Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Melvyn H W YapQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Martyna J GrabowskaQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Chelsie RohrscheibQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Rhiannon JeansQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Michael TroupQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Angelique C PaulkQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Bart van AlphenQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Paul J ShawDepartment of Anatomy & Neurobiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Bruno van SwinderenQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia. b.vanswinderen@uq.edu.au.
University of Queensland · AUMassachusetts General Hospital · USNorthwestern University · USWashington University in St. Louis · US

Funding

FUNCTIONAL ANALYSIS OF SLEEP HOMEOSTASIS IN DROSOPHILAR01NS051305 · NINDS · WASHINGTON UNIVERSITY · PI SHAW, PAUL J · 2005 to 2023
$6.1M
Functional Analysis of Sleep Promoting Neurons in Health and DiseaseR01NS076980 · NINDS · WASHINGTON UNIVERSITY · PI SHAW, PAUL J · 2011 to 2020
$3.3M
NINDS NIH HHS R01 NS051305NINDS NIH HHS R01 NS076980
6 · The paper itself

Abstract

Sleep is a dynamic process comprising multiple stages, each associated with distinct electrophysiological properties and potentially serving different functions. While these phenomena are well described in vertebrates, it is unclear if invertebrates have distinct sleep stages. We perform local field potential (LFP) recordings on flies spontaneously sleeping, and compare their brain activity to flies induced to sleep using either genetic activation of sleep-promoting circuitry or the GABA

Indexed as

AnimalsBrainDipteraDrosophila melanogasterElectrophysiologyFemaleIsoxazolesNervous System Physiological PhenomenaNeuronsSleepSleep StagesTime FactorsgaboxadolIsoxazoles

Identifiers

PMID29180766
PMCPMC5704022
OpenAlexW2769340102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.