ArticleNature neuroscience2018
Altered responses to social chemosignals in autism spectrum disorder.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Olfaction is a Marker of Severity but Not Diagnosis in Anorexia Nervosa: a Systematic Review and Meta-Analysis.Neuropsychology review · 2020Pooled it
- The scent of emotions: A systematic review of human intra- and interspecific chemical communication of emotions.Brain and behavior · 2020Pooled it
- Anomalous Perception of Biological Motion in Autism: A Conceptual Review and Meta-Analysis.Scientific reports · 2020Pooled it
- Titrating the Smell of Fear: Initial Evidence for Dose-Invariant Behavioral, Physiological, and Neural Responses.Psychological science · 2021Trial
- Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis.Journal of autism and developmental disorders · 2020Trial
- Stable clique membership in male mouse societies requires oxytocin-enabled social sensory states.Nature communications · 2026Article
- Voluntary attention regulates acute immune responses in humans.Nature human behaviour · 2026Article
- Scent of a father: Paternal body odors boost interbrain synchrony.Science advances · 2026Article
- JUND-driven stress-responsive astrocytes promote neuronal apoptosis via enhanced gap junction signaling in autism spectrum disorder.Molecular autism · 2026Article
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- Social compatibility in opposite-sex prairie vole pairs is modulated by early-life sleep experience.PLoS biology · 2026Article
- Review
- Neurotype matching in monogamous rodents is modulated by early-life sleep experience.bioRxiv : the preprint server for biology · 2025Article
- Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Altered olfactory responses in Fmr1 KO mice.Scientific reports · 2025Article
- Past, Present, and Future of Human Chemical Communication Research.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Review
- NEGR1 Modulates Mouse Affective Discrimination by Regulating Adult Olfactory Neurogenesis.Biological psychiatry global open science · 2024Article
- Emotion perception through the nose: how olfactory emotional cues modulate the perception of neutral facial expressions in affective disorders.Translational psychiatry · 2024Article
- Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice.Scientific reports · 2024Article
- Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice.Nature communications · 2024Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is characterized by impaired social communication, often attributed to misreading of emotional cues. Why individuals with ASD misread emotions remains unclear. Given that terrestrial mammals rely on their sense of smell to read conspecific emotions, we hypothesized that misreading of emotional cues in ASD partially reflects altered social chemosignaling. We found no difference between typically developed (TD) and cognitively able adults with ASD at explicit detection and perception of social chemosignals. Nevertheless, TD and ASD participants dissociated in their responses to subliminal presentation of these same compounds: the undetected 'smell of fear' (skydiver sweat) increased physiological arousal and reduced explicit and implicit measures of trust in TD but acted opposite in ASD participants. Moreover, two different undetected synthetic putative social chemosignals increased or decreased arousal in TD but acted opposite in ASD participants. These results implicate social chemosignaling as a sensory substrate of social impairment in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.