ArticleNature microbiology2018
Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine.Nature communications · 2026Article
- Quorum sensing regulators AphA and HapR differentially regulate fluvibactin biosynthesis inFrontiers in microbiology · 2026Article
- Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals.bioRxiv : the preprint server for biology · 2024Article
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- Vibrio cholerae Invasion Dynamics of the Chironomid Host Are Strongly Influenced by Aquatic Cell Density and Can Vary by Strain.Microbiology spectrum · 2023Article
- A simple mechanism for integration of quorum sensing and cAMP signalling inbioRxiv : the preprint server for biology · 2023Article
- Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae.mBio · 2023Article
- Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023Review
- Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms.Antibiotics (Basel, Switzerland) · 2023Review
- Intestinal colonization againstAIMS microbiology · 2023Review
- Advances in cholera research: from molecular biology to public health initiatives.Frontiers in microbiology · 2023Review
- Biofilms and Benign Colonic Diseases.International journal of molecular sciences · 2022Review
- Sequestration of a dual function DNA-binding protein byProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Enteric bacterial infection in Drosophila induces whole-body alterations in metabolic gene expression independently of the immune deficiency signaling pathway.G3 (Bethesda, Md.) · 2022Article
- Vibrio cholerae high cell density quorum sensing activates the host intestinal innate immune response.Cell reports · 2022Article
- TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila.Disease models & mechanisms · 2022Article
- Quorum-sensing molecules: Sampling, identification and characterization ofSaudi journal of biological sciences · 2022Article
- Transcriptomic and phenotype analysis revealed the role ofFrontiers in microbiology · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Vibrio cholerae colonizes the human terminal ileum to cause cholera, and the arthropod intestine and exoskeleton to persist in the aquatic environment. Attachment to these surfaces is regulated by the bacterial quorum-sensing signal transduction cascade, which allows bacteria to assess the density of microbial neighbours. Intestinal colonization with V. cholerae results in expenditure of host lipid stores in the model arthropod Drosophila melanogaster. Here we report that activation of quorum sensing in the Drosophila intestine retards this process by repressing V. cholerae succinate uptake. Increased host access to intestinal succinate mitigates infection-induced lipid wasting to extend survival of V. cholerae-infected flies. Therefore, quorum sensing promotes a more favourable interaction between V. cholerae and an arthropod host by reducing the nutritional burden of intestinal colonization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.