ArticleScientific reports2017
A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 278 citations in OpenAlex.
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- Enhanced structural tunability and high sensitivity of a THz metasurface absorber for precise automotive fuel characterization.Scientific reports · 2025Article
- The theory, technology, and application of terahertz metamaterial biosensors: A review.Fundamental research · 2025Review
- Recent progress in terahertz sensors based on graphene metamaterials.Discover nano · 2025Review
- Ultra-compact quintuple-band terahertz metamaterial biosensor for enhanced blood cancer diagnostics.PloS one · 2025Article
- Design and validation of ultra-compact metamaterial-based biosensor for non-invasive cervical cancer diagnosis in terahertz regime.PloS one · 2025Article
- A Thorough Review of Emerging Technologies in Micro- and Nanochannel Fabrication: Limitations, Applications, and Comparison.Micromachines · 2024Review
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- All-Dielectric Metasurface-Based Terahertz Molecular Fingerprint Sensor for Trace Cinnamoylglycine Detection.Biosensors · 2024Article
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- Advancements and Perspectives in Optical Biosensors.ACS omega · 2024Review
- Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor.Sensors (Basel, Switzerland) · 2024Article
- Unlocking the Potential of Phyto Nanotherapeutics in Hepatocellular Carcinoma Treatment: A Review.Journal of hepatocellular carcinoma · 2024Review
- Terahertz Metamaterials for Biosensing Applications: A Review.Biosensors · 2023Review
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- Developing a Novel Terahertz Fabry-Perot Microcavity Biosensor by Incorporating Porous Film for Yeast Sensing.Sensors (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime is an obstacle to extend application in trace biomolecules of cancer antibody or antigen. Here, to overcome water absorption and enhance the THz biosensing sensitivity, two kinds of THz metamaterials biosensor integrated with microfluidics were fabricated and used to detect the Alpha fetoprotein (AFP) and Glutamine transferase isozymes II (GGT-II) of liver cancer biomarker in early stage. There were about 19 GHz resonance shift (5 mu/ml) and 14.2 GHz resonance shift (0.02524 μg/ml) for GGT-II and AFP with a two-gap-metamaterial, respectively, which agreed with simulation results. Those results demonstrated the power and usefulness of metamaterial-assisted THz spectroscopy in trace cancer biomarker molecular detection for biological and chemical sensing. Moreover, for a particular cancer biomarker, the sensitivity could be further improved by optimizing the metamaterial structure and decreasing the permittivity of the substrate. This method might be powerful and potential for special recognition of cancer molecules in the early stage.
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