Evidence map›Paper›PMID 29180606›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Novel BAFF-Receptor Antibody to Natively Folded Recombinant Protein Eliminates Drug-Resistant Human B-cell Malignancies

Hong Qin, Guowei Wei, Ippei Sakamaki, Zhenyuan Dong, Wesley A Cheng, D Lynne Smith, Feng Wen, Han Sun, Kunhwa Kim, Soungchul Cha and 3 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. ZP4: A novel target for CAR-T cell therapy in triple negative breast cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Hong Qin *Beckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California. lkwak@coh.org hoqin@coh.org.
Guowei Wei *Beckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California.
Ippei SakamakiDepartment of Clinical Infectious diseases, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Zhenyuan DongBeckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California.
Wesley A ChengBeckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California.
D Lynne SmithBeckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California.
Feng WenBeckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California.
Han SunBeckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California.
Kunhwa KimDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Soungchul ChaDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Laura BoverDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sattva S NeelapuDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Larry W KwakBeckman Research Institute City of Hope National Medical Center, Toni Stephenson Lymphoma Center, and Department of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, California. lkwak@coh.org hoqin@coh.org.
City Of Hope National Medical Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Toyama · JP

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Translation development of a novel therapeutic antibody against drug-resistant B-cell malignanciesR21CA223141 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KWAK, LARRY W · 2019 to 2020
$414k
NCI NIH HHS P30 CA033572NCI NIH HHS R21 CA223141
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibodies, MonoclonalAntibody-Dependent Cell CytotoxicityAntineoplastic Agents, ImmunologicalB-Cell Activation Factor ReceptorCell Line, TumorDrug Resistance, NeoplasmHumansHybridomasInhibitory Concentration 50Lymphoma, B-CellMiceMice, Inbred BALB CProtein FoldingRecombinant ProteinsXenograft Model Antitumor AssaysAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalB-Cell Activation Factor ReceptorRecombinant ProteinsTNFRSF13C protein, human

Identifiers

PMID29180606
PMCPMC8953840
OpenAlexW2768254821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.