ArticleDevelopment (Cambridge, England)2018
The primary role of zebrafish
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis.bioRxiv : the preprint server for biology · 2026Article
- Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo.Nature communications · 2025Article
- Research progress of nanog gene in fish.Molecular genetics and genomics : MGG · 2024Review
- miR-430 regulates zygotic mRNA during zebrafish embryogenesis.Genome biology · 2024Article
- MaternalFrontiers in cell and developmental biology · 2024Article
- Advances in development of long-term embryonic stem cell-like cultures from a marine fish,Current research in food science · 2024Article
- NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl.PLoS biology · 2023Article
- The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation.Molecular cell · 2022Article
- Pluripotency factors determine gene expression repertoire at zygotic genome activation.Nature communications · 2022Article
- Rapid generation of maternal mutants via oocyte transgenic expression of CRISPR-Cas9 and sgRNAs in zebrafish.Science advances · 2021Article
- Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes.BMC genomics · 2020Article
- Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.PLoS biology · 2020Article
- Article
- Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish.Developmental biology · 2020Article
- Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation.PLoS genetics · 2020Article
- Recording development with single cell dynamic lineage tracing.Development (Cambridge, England) · 2019Review
- Mechanisms regulating zygotic genome activation.Nature reviews. Genetics · 2019Review
- Pou5f3, SoxB1, and Nanog remodel chromatin on high nucleosome affinity regions at zygotic genome activation.Genome research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The role of the zebrafish transcription factor Nanog has been controversial. It has been suggested that Nanog is primarily required for the proper formation of the extra-embryonic yolk syncytial layer (YSL) and only indirectly regulates gene expression in embryonic cells. In an alternative scenario, Nanog has been proposed to directly regulate transcription in embryonic cells during zygotic genome activation. To clarify the roles of Nanog, we performed a detailed analysis of zebrafish
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.