ArticlePhysiological reports2017
Validity and variability of xBRS: instantaneous cardiac baroreflex sensitivity.
Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Impact of positive end-expiratory pressure on autonomic nervous system activity and its interaction with cerebrovascular reactivity - an experimental study.Journal of clinical monitoring and computing · 2026Article
- Relationship between the autonomic nervous system and cerebral autoregulation during controlled breathing.European journal of applied physiology · 2026Article
- Assessment of heart rate variability, baroreceptor sensitivity and its association with serum catestatin in vertigo patients: An observational study.Journal of family medicine and primary care · 2026Article
- Paroxysmal sympathetic hyperactivity risk modeling based on transients in time series describing the autonomic nervous system and cerebral hemodynamics.Acta neurochirurgica · 2025Article
- Autonomic and baroreflex regulations in syndromic and non-syndromic aortopathies: a case-control study.Frontiers in physiology · 2025Article
- Association between temporal patterns of baroreflex sensitivity after traumatic brain injury and prognosis: a preliminary study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Automated analysis of finger blood pressure recordings provides insight in determinants of baroreflex sensitivity and heart rate variability-the HELIUS study.Medical & biological engineering & computing · 2023Article
- Baroreflex Sensitivity Assessment Using the Sequence Method with Delayed Signals in End-Stage Renal Disease Patients.Sensors (Basel, Switzerland) · 2022Article
- Is the Association Between Education and Sympathovagal Balance Mediated by Chronic Stressors?International journal of behavioral medicine · 2022Article
- Post-Acute Effect of SARS-CoV-2 Infection on the Cardiac Autonomic Function.International journal of general medicine · 2022Article
- Is the Sympathetic System Detrimental in the Setting of Septic Shock, with Antihypertensive Agents as a Counterintuitive Approach? A Clinical Proposition.Journal of clinical medicine · 2021Review
- Editorial: Cardiorespiratory Coupling-Novel Insights for Integrative Biomedicine.Frontiers in neuroscience · 2021Article
- Assessment of baroreceptor reflex sensitivity in young obese Saudi males at rest and in response to physiological challenges.Physiological reports · 2020Article
- Interpretation of Heart Rate Variability: The Art of Looking Through a Keyhole.Frontiers in neuroscience · 2020Article
- Associations Between Child Maltreatment, Autonomic Regulation, and Adverse Cardiovascular Outcome in an Urban Population: The HELIUS Study.Frontiers in psychiatry · 2020Article
- Instantaneous Cardiac Baroreflex Sensitivity: xBRS Method Quantifies Heart Rate Blood Pressure Variability Ratio at Rest and During Slow Breathing.Frontiers in neuroscience · 2020Article
- Biphasic changes in spontaneous cardiovagal baroreflex sensitivity during passive hyperthermia.Scientific reports · 2019Article
- Cross-Wavelet Time-Frequency Analysis Reveals Sympathetic Contribution to Baroreflex Sensitivity as Cause of Variable Phase Delay Between Blood Pressure and Heart Rate.Frontiers in neuroscience · 2019Article
- Validity and variability of xBRS: instantaneous cardiac baroreflex sensitivity.Physiological reports · 2017Article
- Effect of energy drink consumption on baroreceptor sensitivity in young normal weight and overweight/obese males.Pakistan journal of medical sciencesArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous oscillations of blood pressure (BP) and interbeat interval (IBI) may reveal important information on the underlying baroreflex control and regulation of BP We evaluated the method of continuously measured instantaneous baroreflex sensitivity by cross correlation (xBRS) validating its mean value against the gold standard of phenylephrine (Phe) and nitroprusside (SNP) bolus injections, and focusing on its spontaneous changes quantified as variability around the mean. For this purpose, we analyzed data from an earlier study of eight healthy males (aged 25-46 years) who had received Phe and SNP in conditions of baseline and autonomic blocking agents: atropine, propranolol, and clonidine. Average xBRS corresponds well to Phe/SNP-BRS, with xBRS levels ranging from 1.2 (atropine) to 102 msec/mmHg (subject asleep under clonidine). Time shifts from BP- to IBI-signal increased from ≤1 sec (maximum correlations within the current heartbeat) to 3-5 sec (under atropine). Plotted on a logarithmic vertical scale, xBRS values show 40% variability (defined as SD/mean) over the whole range in the various conditions, except twice when the subjects had fallen asleep and it dropped to 20%. The xBRS oscillates at frequencies of 0.1 Hz and lower, dominant between 0.02-0.05 Hz. Although xBRS is the result of IBI/BP-changes, no linear coherence was found in the cross-spectra of the xBRS-signal and IBI or BP We speculate that the level of variability in the xBRS-signal may act as a probe into the central nervous condition, as evidenced in the two subjects who fell asleep with high xBRS and only 20% of relative variation.
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