ArticleThe Journal of biological chemistry2018
A neutralizing antibody that blocks delivery of the enzymatic cargo of
Open access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub-Types.Biotechnology and bioengineering · 2026Article
- Immune Aspects of Clostridioides difficile Infection and Vaccine Development.Infectious disease clinics of North America · 2025Review
- Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary Clostridioides difficile Isolates.The Journal of infectious diseases · 2025Article
- The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice.PLoS pathogens · 2025Article
- Mouse monoclonal antibodies againstInfection and immunity · 2025Article
- A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile.bioRxiv : the preprint server for biology · 2025Article
- The interplay between host immunity andmBio · 2025Review
- Mechanisms ofFrontiers in cellular and infection microbiology · 2025Review
- De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants.Nature communications · 2024Article
- Exploring the Toxin-Mediated Mechanisms inMicroorganisms · 2024Review
- Recent advances in fecal microbiota transplantation forFrontiers in microbiomes · 2024Review
- Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targetingbioRxiv : the preprint server for biology · 2023Article
- Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo.PLoS pathogens · 2023Article
- Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development.The FEBS journal · 2023Review
- Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions.Infection and immunity · 2023Article
- Catalytic DxD motif caged in Asx-turn and Met-aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors.Scientific reports · 2022Article
- Paeniclostridium sordellii uterine infection is dependent on the estrous cycle.PLoS pathogens · 2022Article
- The Current Knowledge onPathogens (Basel, Switzerland) · 2022Review
- Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics.Nature reviews. Microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Heather K KrohFrom the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2363.
Ramyavardhanee ChandrasekaranFrom the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2363.
Zhifen ZhangDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Kim RosenthalMedImmune LLC, Gaithersburg, Maryland 20878-2204.
Rob WoodsMedImmune LLC, Gaithersburg, Maryland 20878-2204.
Xiaofang JinMedImmune LLC, Gaithersburg, Maryland 20878-2204.
Andrew C NyborgMedImmune LLC, Gaithersburg, Maryland 20878-2204.
G Jonah RaineyMedImmune LLC, Gaithersburg, Maryland 20878-2204.
Paul WarrenerMedImmune LLC, Gaithersburg, Maryland 20878-2204.
Roman A MelnykDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Benjamin W SpillerFrom the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2363.
D Borden LacyFrom the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2363, borden.lacy@vanderbilt.edu.
Vanderbilt University Medical Center · USHospital for Sick Children · CAUniversity of Toronto · CAVA Tennessee Valley Healthcare System · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MStructural mechanisms of Clostridium difficile pathogenesisR01AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LACY, DANA BORDEN · 2011 to 2020
$3.9MStructural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2MCopN mechanism as a key to understanding Type Three Secretion in bacteriaR01AI108778 · NIAID · VANDERBILT UNIVERSITY · PI SPILLER, BENJAMIN W · 2014 to 2018
$2.0MCrystallographic AutomationS10RR026915 · NCRR · VANDERBILT UNIVERSITY · PI IVERSON, T M · 2010 to 2010
$490kThe role of toxins in Clostridium difficile infection pathogenesisI01BX002943 · VA · VETERANS HEALTH ADMINISTRATION · PI LACY, DANA BORDEN · 2016 to 2025
–BLRD VA I01 BX002943NCRR NIH HHS S10 RR026915NIAID NIH HHS R01 AI095755NIAID NIH HHS R01 AI108778NIAID NIH HHS R37 AI095755NIDDK NIH HHS P30 DK058404
Abstract
PubMed holds no abstract for this paper.
Indexed as
Antibodies, MonoclonalAntibodies, NeutralizingBacterial ToxinsCaco-2 CellsClostridioides difficileCrystallography, X-RayCytosolEnterotoxinsHumansHydrogen-Ion ConcentrationMicroscopy, Electronrac1 GTP-Binding ProteinRubidiumAntibodies, MonoclonalAntibodies, NeutralizingBacterial ToxinsEnterotoxinsrac1 GTP-Binding ProteinRubidiumtcdA protein, Clostridium difficileantibodybacterial pathogenesisbacterial toxinelectron microscopy (EM)membrane transportneutralizationtoxinX-ray crystallography
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.