Evidence map›Paper›PMID 29180445›Full record

ArticleJournal of lipid research2018

Flipping the cyclooxygenase (

Xinzhi Li, Liudmila L Mazaleuskaya, Chong Yuan, Laurel L Ballantyne, Hu Meng, William L Smith, Garret A FitzGerald, Colin D Funk

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The enzymology of the human prostanoid pathway.Molecular biology reports · 2020
    Review
  9. Perivascular adipose tissue-derived extracellular vesicle miR-221-3p mediates vascular remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  10. Article
  11. Review
  12. Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xinzhi LiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Liudmila L MazaleuskayaInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Chong YuanDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI.
Laurel L BallantyneDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Hu MengInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
William L SmithDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Colin D FunkDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada funkc@queensu.ca.
Queen's University · CATranslational Therapeutics (United States) · USUniversity of Michigan–Ann Arbor · US

Funding

Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ALTMAN, RUSS BIAGIO · 2012 to 2016
$18.5M
TRAINING GRANT IN HEMOSTASIS AND THROMBOSIST32HL007971 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rodney M Camire · 2001 to 2026
$10.6M
NHLBI NIH HHS T32 HL007971NHLBI NIH HHS U54 HL117798
6 · The paper itself

Abstract

Two prostaglandin (PG) H synthases encoded by

Indexed as

AnimalsHEK293 CellsHumansIsoenzymesMiceMice, Inbred C57BLProstaglandin-Endoperoxide SynthasesIsoenzymesProstaglandin-Endoperoxide Synthasesanimal modeleicosanoidgene targetingmacrophageplateletprostaglandin

Identifiers

PMID29180445
PMCPMC5748500
OpenAlexW2770705758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.