Evidence map›Paper›PMID 29180443›Full record

ArticleJournal of lipid research2018

Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.

Xinzhi Li, Liudmila L Mazaleuskaya, Laurel L Ballantyne, Hu Meng, Garret A FitzGerald, Colin D Funk

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  3. Archives of Razi Institute · 2023
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  8. Synthesis, Inhibitory Activity, andACS medicinal chemistry letters · 2021
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  10. Article
  11. Article
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  13. Article
  14. Article
  15. Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
    Article
  16. Article
  17. Flipping the cyclooxygenase (Journal of lipid research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xinzhi LiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Liudmila L MazaleuskayaInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Laurel L BallantyneDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Hu MengInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Colin D FunkDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada funkc@queensu.ca.
Queen's University · CATranslational Therapeutics (United States) · US

Funding

Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ALTMAN, RUSS BIAGIO · 2012 to 2016
$18.5M
TRAINING GRANT IN HEMOSTASIS AND THROMBOSIST32HL007971 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rodney M Camire · 2001 to 2026
$10.6M
NHLBI NIH HHS T32 HL007971NHLBI NIH HHS U54 HL117798
6 · The paper itself

Abstract

Both cyclooxygenase (COX)-1 and COX-2, encoded by

Indexed as

AnimalsInflammationIsoenzymesLipidsLipopolysaccharidesMiceMice, Inbred C57BLProstaglandin-Endoperoxide SynthasesIsoenzymesLipidsLipopolysaccharidesProstaglandin-Endoperoxide Synthasesanimal modelcyclooxygenaseeicosanoidlipopolysaccharidemacrophageprostaglandin, gene targeting

Identifiers

PMID29180443
PMCPMC5748501
OpenAlexW2770186014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.