Evidence map›Paper›PMID 29180425›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Interaction of intramembrane metalloprotease SpoIVFB with substrate Pro-σ

Sabyasachi Halder, Daniel Parrell, Douglas Whitten, Michael Feig, Lee Kroos

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sabyasachi HalderDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Daniel ParrellDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Douglas WhittenDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Michael FeigDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Lee KroosDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 kroos@msu.edu.

Funding

SWITCH GOVERNING BACILLUS MOTHER CELL GENE EXPRESSIONR01GM043585 · NIGMS · MICHIGAN STATE UNIVERSITY · PI KROOS, LEE R · 1995 to 2021
$4.8M
Protein structure refinement through effective sampling and scoringR01GM084953 · NIGMS · MICHIGAN STATE UNIVERSITY · PI FEIG, MICHAEL · 2008 to 2017
$2.5M
NIGMS NIH HHS R01 GM043585NIGMS NIH HHS R01 GM084953
6 · The paper itself

Abstract

Intramembrane proteases (IPs) cleave membrane-associated substrates in nearly all organisms and regulate diverse processes. A better understanding of how these enzymes interact with their substrates is necessary for rational design of IP modulators. We show that interaction of

Indexed as

Bacillus subtilisBacterial ProteinsBinding SitesEndopeptidasesMembrane ProteinsMolecular Docking SimulationProtein BindingSigma FactorBacterial ProteinsEndopeptidasesMembrane Proteinspro-sigmaK protein, Bacillus subtilisSigma FactorspoIVFB protein, Bacillus subtilisBacillus subtilisintramembrane proteaseregulated intramembrane proteolysisSpoIVFBsporulation

Identifiers

PMID29180425
PMCPMC5740621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.