Evidence map›Paper›PMID 29180399›Full record

ArticleBlood2018

Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma.

Rebecca Kohnken, Jing Wen, Bethany Mundy-Bosse, Kathleen McConnell, Ashleigh Keiter, Leah Grinshpun, Alex Hartlage, Max Yano, Betina McNeil, Nitin Chakravarti and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. "Next top" mouse models advancing CTCL research.Frontiers in cell and developmental biology · 2024
    Review
  4. Review
  5. Review
  6. A BRD4 PROTAC nanodrug for glioma therapyActa pharmaceutica Sinica. B · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Emerging epigenetic-modulating therapies in lymphoma.Nature reviews. Clinical oncology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Rebecca KohnkenDepartment of Veterinary Biosciences.
Jing WenComprehensive Cancer Center.
Bethany Mundy-BosseComprehensive Cancer Center.
Kathleen McConnellComprehensive Cancer Center.
Ashleigh KeiterComprehensive Cancer Center.
Leah GrinshpunComprehensive Cancer Center.
Alex HartlageComprehensive Cancer Center.
Max YanoComprehensive Cancer Center.
Betina McNeilComprehensive Cancer Center.
Nitin ChakravartiNationwide Children's Hospital, The Ohio State University, Columbus, OH.
Basem WilliamComprehensive Cancer Center.
James E BradnerDana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and.
Michael A CaligiuriComprehensive Cancer Center.
Pierluigi PorcuComprehensive Cancer Center.
Anjali MishraComprehensive Cancer Center.
Comprehensive Blood & Cancer Center · USHarvard University · USNationwide Children's Hospital · USThe Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Mouse Pathobiology: Models of Human DiseaseT32OD010429 · OD · OHIO STATE UNIVERSITY · PI NIEWIESK, STEFAN, OGLESBEE, MICHAEL J · 2012 to 2017
$1.3M
NCI NIH HHS P30 CA016058NIH HHS T32 OD010429
6 · The paper itself

Abstract

MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), an often-fatal malignancy of skin-homing CD4

Indexed as

AnimalsBromodomain Containing ProteinsCD4-Positive T-LymphocytesCell Cycle ProteinsCells, CulturedDown-RegulationGene Expression Regulation, NeoplasticHumansLymphoma, T-Cell, CutaneousMiceMice, Inbred C57BLMice, TransgenicMicroRNAsNuclear ProteinsOncogenesSkin NeoplasmsBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsMicroRNAsMIRN29a microRNA, humanMIRN29 microRNA, mouseNuclear ProteinsTranscription Factors

Identifiers

PMID29180399
PMCPMC5814934
OpenAlexW2768331219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.