Evidence map›Paper›PMID 29180325›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2017

[Correlation between ectopic fat accumulation and insulin sensitivity in obese individuals with different glucose tolerance levels].

Shui-Qing Lai, Zhen-Zhen Hong, Hong-Mei Chen, Jin-Xin Lin, Jian Kuang, Yan-Bing Li

Registry-linked trialAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05597709 (Prevalence of Metabolic Associated Fatty Liver Disease in Patients With Type 2 Diabetes in Jiangsu Province of China), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05597709 recruitingnot on this mapstarted 2022, after this paper: background citation

Prevalence of Metabolic Associated Fatty Liver Disease in Patients With Type 2 Diabetes in Jiangsu Province of China: a Prospective, Multicenter, Real-world Study

TypeobservationalSponsorWuxi Hisky Medical Technology Co LtdRan2022 to 2027Enrolled2,900ConditionsType 2 Diabetes Mellitus in Remission, Metabolic Associated Fatty Liver DiseaseArmsUltrasound attenuation parameter measurement, fasting blood glucose and fasting insulin determination
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shui-Qing LaiDepartment of Endocrinology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China. E-mail: LSQ_GD2017@163.com.
Zhen-Zhen Hong
Hong-Mei Chen
Jin-Xin Lin
Jian Kuang
Yan-Bing Li
Guangdong Academy of Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the correlation between liver and skeletal muscle fat contents and insulin resistance in obese individuals with different levels of glucose tolerance.

methods

resultsTen non-obese individuals with normal glucose tolerance (NGT), 9 obese individuals with NGT, and 7 obese individuals with impaired glucose tolerance (IGT) were enrolled in this study. All the participants were examined for insulin sensitivity by hyperinsulinemic-euglycemic clamp and for liver and skeletal muscle fat accumulation quantified by proton magnetic resonance spectroscopy (1H MRS). The data were collected from the subjects including somatometric measurements, fasting plasma glucose, 2-h plasma glucose (2hPG), fasting insulin, and blood biochemistry. Linear correlation analysis and multiple linear stepwise regression analysis were used to analyze the relationship between ectopic fat accumulation and insulin resistance.

resultsThe glucose infusion rates (GIR, presented as the M value) differed significantly among IGT-obese (3.95∓1.66 mg·kg

conclusionsLiver fat accumulation, but not skeletal muscle fat accumulation, is correlated with insulin resistance and impaired glucose metabolism.

Indexed as

Insulin ResistanceAdipose TissueBlood GlucoseBody Mass IndexGlucose Clamp TechniqueGlucose Tolerance TestHumansInsulinLiverMuscle, SkeletalObesityBlood GlucoseInsulin

Identifiers

PMID29180325
PMCPMC6779651
OpenAlexW2990702050

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Registered trials

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