Evidence map›Paper›PMID 29180076›Full record

GuidelineRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2018

Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.

Vincent Grégoire, Mererid Evans, Quynh-Thu Le, Jean Bourhis, Volker Budach, Amy Chen, Abraham Eisbruch, Mei Feng, Jordi Giralt, Tejpal Gupta and 23 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Head-to-Head Comparison of [Molecular imaging and biology · 2022
    Trial
  12. Trial
  13. Article
  14. Comparison of induction chemotherapy followed by concurrent chemoradiotherapy versus neoadjuvant chemotherapy followed by surgery and (chemo)radiotherapy in locoregionally advanced hypopharyngeal carcinoma: a prospective cohort study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Vincent GrégoireUniversité catholique de Louvain, St-Luc University Hospital, Department of Radiation Oncology, Brussels, Belgium. Electronic address: Vincent.gregoire@uclouvain.be.
Mererid EvansVelindre Cancer Centre, Department of Radiation Oncology, Wales, UK.
Quynh-Thu LeStanford University School of Medicine, Department of Radiation Oncology, USA.
Jean BourhisCHUV and University of Lausanne, Department of Radiation Oncology, Switzerland.
Volker BudachCharité University Hospital, Department of Radio-oncology and Radiotherapy, Berlin, Germany.
Amy ChenSun Yat-Sen University, Cancer Centre, Department of Radiation Oncology, Guangzhou, China.
Abraham EisbruchUniversity of Michigan Health System, Department of Radiation Oncology, Ann Arbor, USA.
Mei FengDepartment of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China.
Jordi GiraltVall d'Hebron University Hospital, Radiation Oncology Service, Barcelona, Spain.
Tejpal GuptaTata Memorial Hospital, Department of Radiation Oncology, Mumbai, India.
Marc HamoirUniversité catholique de Louvain, St-Luc University Hospital, Department of Head and Neck Surgery, Brussels, Belgium.
Juliana K HelitoHospital Israelita Albert Einstein, Department of Radiation Oncology, Sao Paulo, Brazil.
Chaosu HuFudan University Shanghai Cancer Center, Department of Radiation Oncology, China.
Keith HunterUniversity of Sheffield, School of Clinical Dentistry, Unit of Oral and Maxillofacial Pathology, UK.
Jorgen JohansenOdense University Hospital, Department of Oncology, Denmark.
Johannes KaandersRadboud University Medical Centre, Department of Radiation Oncology, Nijmegen, The Netherlands.
Sarbani Ghosh LaskarTata Memorial Hospital, Department of Radiation Oncology, Mumbai, India.
Anne LeeUniversity of Hong Kong and University of Hong Kong Shenzhen Hospital, Department of Clinical Oncology, Hong Kong, China.
Philippe MaingonHôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Department of Radiation Oncology, Paris, France.
Antti MäkitieUniversity of Helsinki and Helsinki University Hospital, Department of Otorhinolaryngology - Head & Neck Surgery, Finland.
Francesco Micciche'Universita' Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Polo Scienze Oncologiche ed Ematologiche, Rome, Italy.
Piero NicolaiUniversity of Brescia, Divisions of Otorhinolaryngology - Head and Neck Surgery, Italy.
Brian O'SullivanUniversity of Toronto, The Princess Margaret Hospital, Department of Radiation Oncology, Canada.
Adela PoitevinMedica Sur, Unit for Radiotherapy, México DF, Mexico.
Sandro PorcedduPrincess Alexander Hospital, Department of Radiation Oncology, Brisbane, Australia.
Krzysztof SkładowskiInstitute of Oncology, Maria Sklodowska-Curie Cancer Center, Gliwice, Poland.
Silke TribiusAsklepios St. Georg Hospital, Hermann-Holthusen Institute for Radiotherapy, Hamburg, Germany.
John WaldronUniversity of Toronto, The Princess Margaret Hospital, Department of Radiation Oncology, Canada.
Joseph WeeNational Cancer Centre Singapore, Division of Radiation Oncology, Singapore.
Min YaoCase Western Reserve University Hospital, Department of Radiation Oncology, Cleveland, USA.
Sue S YomUniversity of California-San Francisco, Department of Radiation Oncology, USA.
Frank ZimmermannUniversity Hospital Basel, Clinic of Radiotherapy and Radiation Oncology, Switzerland.
Cai GrauAarhus University Hospital, Department of Oncology, Denmark.

Funding

UM LAPs- U10 GrantU10CA180801 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZALUPSKI, MARK M · 2014 to 2018
$3.7M
6 · The paper itself

Abstract

purposeFew studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy.

methodFor each anatomic location within the larynx, hypopharynx, oropharynx and oral cavity, and for each T-stage, the DAHANCA proposal has been comprehensively reviewed and edited to include anatomic knowledge into the geometric Clinical Target Volume (CTV) delineation concept. A first proposal was put forward by the leading authors of this publication (VG and CG) and discussed with opinion leaders in head and neck radiation oncology from Europe, Asia, Australia/New Zealand, North America and South America to reach a worldwide consensus.

resultsThis consensus proposes two CTVs for the primary tumour, the so called CTV-P1 and CVT-P2, corresponding to a high and lower tumour burden, and which should be associated with a high and a lower dose prescription, respectively.

conclusionImplementation of these guidelines in the daily practice of radiation oncology should contribute to reduce treatment variations from clinicians to clinicians, facilitate the conduct of multi-institutional clinical trials, and contribute to improved care of patients with head and neck carcinoma.

Indexed as

Carcinoma, Squamous CellConsensusHead and Neck NeoplasmsHumansHypopharyngeal NeoplasmsLaryngeal NeoplasmsMouth NeoplasmsOropharyngeal NeoplasmsRadiotherapy Planning, Computer-AssistedSquamous Cell Carcinoma of Head and NeckTumor BurdenClinical Target Volume (CTV)Gross Tumour Volume (GTV)GuidelineHead and neckRadiotherapy

Identifiers

PMID29180076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.