Evidence map›Paper›PMID 29179995›Full record

ArticleBiochimica et biophysica acta. Biomembranes2018

Non-bilayer structures in mitochondrial membranes regulate ATP synthase activity.

Sardar E Gasanov, Aleksandr A Kim, Lev S Yaguzhinsky, Ruben K Dagda

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Decoding the Hot-Mitochondrion Paradox.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
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  11. Directed proton transfer from FBiophysical reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Sardar E GasanovApplied Mathematics and Informatics Department, M.V. Lomonosov Moscow State University Branch, 22-a Amir Timur Avenue, Tashkent 100061, Uzbekistan; Bioenergetics Department, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Vorobievy Gory, Moscow 119991, Russia. Electronic address: sgasanov@yahoo.com.
Aleksandr A KimApplied Mathematics and Informatics Department, M.V. Lomonosov Moscow State University Branch, 22-a Amir Timur Avenue, Tashkent 100061, Uzbekistan. Electronic address: kaa9321@gmail.com.
Lev S YaguzhinskyBioenergetics Department, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Vorobievy Gory, Moscow 119991, Russia. Electronic address: yag@genebee.msu.su.
Ruben K DagdaDepartment of Pharmacology, University of Nevada, Reno School of Medicine, 1664 North Virginia Street, Reno, Nevada 89557, USA. Electronic address: rdagda@medicine.nevada.edu.
Lomonosov Moscow State University · RUMoscow State University · TJUniversity of Nevada, Reno · US

Funding

Cell Biology of Signaling across MembranesP20GM103554 · NIGMS · UNIVERSITY OF NEVADA RENO · PI VON BARTHELD, CHRISTOPHER S · 2012 to 2016
$8.0M
NIGMS NIH HHS P20 GM103554
6 · The paper itself

Abstract

Cardiolipin (CL) is an anionic phospholipid at the inner mitochondrial membrane (IMM) that facilitates the formation of transient non-bilayer (non-lamellar) structures to maintain mitochondrial integrity. CL modulates mitochondrial functions including ATP synthesis. However, the biophysical mechanisms by which CL generates non-lamellar structures and the extent to which these structures contribute to ATP synthesis remain unknown. We hypothesized that CL and ATP synthase facilitate the formation of non-bilayer structures at the IMM to stimulate ATP synthesis. By using

Indexed as

Adenosine TriphosphateAnimalsCardiolipinsCattleDicyclohexylcarbodiimideLipid BilayersMagnetic Resonance SpectroscopyMitochondria, HeartMitochondrial MembranesMitochondrial Proton-Translocating ATPasesModels, BiologicalMolecular Docking SimulationProtein BindingProtonsUnilamellar LiposomesAdenosine TriphosphateCardiolipinsDicyclohexylcarbodiimideLipid BilayersMitochondrial Proton-Translocating ATPasesProtonsUnilamellar LiposomesATP synthaseCardiolipinCardiotoxinInverted micellesMitochondriaNonbilayer structures

Identifiers

PMID29179995
PMCPMC5755587
OpenAlexW2769523034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.