Evidence map›Paper›PMID 29179814›Full record

ArticleeLife2017

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life.

Sean Froudist-Walsh, Michael Ap Bloomfield, Mattia Veronese, Jasmin Kroll, Vyacheslav R Karolis, Sameer Jauhar, Ilaria Bonoldi, Philip K McGuire, Shitij Kapur, Robin M Murray and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. An etiological approach to psychosis: potential benefits for treatment, research and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
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  12. The clinical characterization of the patient with primary psychosis aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Non-Genetic Factors in Schizophrenia.Current psychiatry reports · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. Plasticity in the Working Memory System: Life Span Changes and Response to Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Sean Froudist-WalshDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.ORCID 0000-0003-4070-067X
Michael Ap BloomfieldDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Mattia VeroneseDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Jasmin KrollDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Vyacheslav R KarolisDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Sameer JauharDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Ilaria BonoldiDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Philip K McGuireDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Shitij KapurDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Chiara NosartiDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Oliver HowesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.ORCID 0000-0002-2928-1972
King's College London · GBAllen Institute for Brain Science · US

Funding

Medical Research Council G0700995Medical Research Council MC-A656-5QD30Medical Research Council MC_U120097115Medical Research Council MR/K004867/1Medical Research Council MR/N026063/1Wellcome TrustWellcome Trust 094849/Z/10/Z
6 · The paper itself

Abstract

Perinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched controls born at full term using [18F]-DOPA PET and structural MRI. Dopamine synthesis capacity was reduced in the perinatal brain injury group relative to those without brain injury (Cohen's

Indexed as

AdultBrain InjuriesDopamineDopaminergic NeuronsFemaleHippocampusHumansLondonMagnetic Resonance ImagingMalePositron-Emission TomographyDopaminebrain injurybrain volumedopaminehumanimagingneurosciencepreterm

Identifiers

PMID29179814
PMCPMC5705207
OpenAlexW2613498043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.