Evidence map›Paper›PMID 29179738›Full record

ArticleStem cell research & therapy2017

Laser-modified titanium surfaces enhance the osteogenic differentiation of human mesenchymal stem cells.

Tatiana A B Bressel, Jana Dara Freires de Queiroz, Susana Margarida Gomes Moreira, Jéssyca T da Fonseca, Edson A Filho, Antônio Carlos Guastaldi, Silvia Regina Batistuzzo de Medeiros

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

  1. Differential Response of Stro-1Journal of functional biomaterials · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tatiana A B BresselDepartamento de Biologia Celular e Genética, CB-UFRN, Universidade Federal do Rio Grande do Norte, Campus Universitário, Lagoa Nova, 59072-970, Natal, RN, Brazil.
Jana Dara Freires de QueirozDepartamento de Biologia Celular e Genética, CB-UFRN, Universidade Federal do Rio Grande do Norte, Campus Universitário, Lagoa Nova, 59072-970, Natal, RN, Brazil.
Susana Margarida Gomes MoreiraDepartamento de Biologia Celular e Genética, CB-UFRN, Universidade Federal do Rio Grande do Norte, Campus Universitário, Lagoa Nova, 59072-970, Natal, RN, Brazil.
Jéssyca T da FonsecaDepartamento de Biologia Celular e Genética, CB-UFRN, Universidade Federal do Rio Grande do Norte, Campus Universitário, Lagoa Nova, 59072-970, Natal, RN, Brazil.
Edson A FilhoDepartamento de Físico-Química, Instituto de Química de Araraquara-UNESP, Araraquara, SP, Brazil.
Antônio Carlos GuastaldiDepartamento de Físico-Química, Instituto de Química de Araraquara-UNESP, Araraquara, SP, Brazil.
Silvia Regina Batistuzzo de MedeirosDepartamento de Biologia Celular e Genética, CB-UFRN, Universidade Federal do Rio Grande do Norte, Campus Universitário, Lagoa Nova, 59072-970, Natal, RN, Brazil. sbatistu@gmail.com.
Universidade Federal do Rio Grande do Norte · BRCentro Universitário de Araraquara · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 404762/2012-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 465656/2014-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 23038.008617/2010-21
6 · The paper itself

Abstract

backgroundTitanium surfaces have been modified by various approaches with the aim of improving the stimulation of osseointegration. Laser beam (Yb-YAG) treatment is a controllable and flexible approach to modifying surfaces. It creates a complex surface topography with micro and nano-scaled patterns, and an oxide layer that can improve the osseointegration of implants, increasing their usefulness as bone implant materials.

methodsLaser beam irradiation at various fluences (132, 210, or 235 J/cm

resultsThe best titanium surface was that produced by laser beam irradiation at 235 J/cm

conclusionsThe laser-treated titanium surface modulated cellular behavior depending on the cell type, and stimulated osteogenic differentiation. This evidence supports the potential use of laser-processed titanium surfaces as bone implant materials, and their use in regenerative medicine could promote better outcomes.

Indexed as

Alkaline PhosphataseBiomarkersBone Morphogenetic Protein 2Cell DifferentiationCore Binding Factor Alpha 1 SubunitGene ExpressionHumansLasersMesenchymal Stem CellsMicroscopy, Electron, ScanningOsteoblastsOsteocalcinOsteogenesisOsteopontinPrimary Cell CultureProstheses and ImplantsAlkaline PhosphataseALPL protein, humanBiomarkersBMP2 protein, humanBone Morphogenetic Protein 2Core Binding Factor Alpha 1 SubunitOsteocalcinOsteopontinRUNX2 protein, humanSPP1 protein, humanTitaniumBiocompatibilityHuman umbilical cordLaser beam (Yb-YAG)Mesenchymal stem cellsOsteoinductionSurface modificationTitanium

Identifiers

PMID29179738
PMCPMC5704576
OpenAlexW2770184809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.