ArticleJournal of neurotrauma2018
High-Fidelity Measures of Whole-Brain Functional Connectivity and White Matter Integrity Mediate Relationships between Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.
Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Neuroimaging of Parkinson's Disease
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward.Reviews in endocrine & metabolic disorders · 2022Pooled it
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Mild traumatic brain injury increases vulnerability to post-traumatic stress disorder in rats and the possible role of hippocampal DNA methylation.Frontiers in behavioral neuroscience · 2025Article
- The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Article
- One size does not fit all: notable individual variation in brain activity correlates of antidepressant treatment response.Frontiers in psychiatry · 2024Article
- Insights from personalized models of brain and behavior for identifying biomarkers in psychiatry.Neuroscience and biobehavioral reviews · 2023Review
- Accuracy and reliability of diffusion imaging models.NeuroImage · 2022Article
- Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury.Frontiers in neuroscience · 2022Article
- ENIGMA brain injury: Framework, challenges, and opportunities.Human brain mapping · 2022Review
- Raloxifene Mitigates Emotional Deficits after Mild Traumatic Brain Injury in Mice.Neurotrauma reports · 2022Article
- Striving toward translation: strategies for reliable fMRI measurement.Trends in cognitive sciences · 2021Review
- Relationship between depression and dorsolateral prefronto-thalamic tract injury in patients with mild traumatic brain injury.Scientific reports · 2020Article
- Defining Individual-Specific Functional Neuroanatomy for Precision Psychiatry.Biological psychiatry · 2020Review
- MRI-based measures of intracortical myelin are sensitive to a history of TBI and are associated with functional connectivity.NeuroImage · 2019Article
- The Protective Effects of Supportive Parenting on the Relationship Between Adolescent Poverty and Resting-State Functional Brain Connectivity During Adulthood.Psychological science · 2019Article
- The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke.Neurobiology of disease · 2019Review
- Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study.JAMA psychiatry · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) disrupts brain communication and increases risk for post-traumatic stress disorder (PTSD). However, mechanisms by which TBI-related disruption of brain communication confers PTSD risk have not been successfully elucidated in humans. This may be in part because functional MRI (fMRI), the most common technique for measuring functional brain communication, is unreliable for characterizing individual patients. However, this unreliability can be overcome with sufficient within-individual data. Here, we examined whether relationships could be observed among TBI, structural and functional brain connectivity, and PTSD severity by collecting ∼3.5 hours of resting-state fMRI and diffusion tensor imaging (DTI) data in each of 26 United States military veterans. We observed that a TBI history was associated with decreased whole-brain resting-state functional connectivity (RSFC), while the number of lifetime TBIs was associated with reduced whole-brain fractional anisotropy (FA). Both RSFC and FA explained independent variance in PTSD severity, with RSFC mediating the TBI-PTSD relationship. Finally, we showed that large amounts of per-individual data produced highly reliable RSFC measures, and that relationships among TBI, RSFC/FA, and PTSD could not be observed with typical data quantities. These results demonstrate links among TBI, brain connectivity, and PTSD severity, and illustrate the need for precise characterization of individual patients using high-data fMRI scanning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.