Evidence map›Paper›PMID 29179480›Full record

ArticleOncotarget2017

Neutrophil/lymphocyte ratio is a more sensitive systemic inflammatory response biomarker than platelet/lymphocyte ratio in the prognosis evaluation of unresectable pancreatic cancer.

Yuan Gao, Wen-Jie Wang, Qiaoming Zhi, Meng Shen, Min Jiang, Xiaojie Bian, Fei-Ran Gong, Chong Zhou, Lian Lian, Meng-Yao Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. PD-L1Technology in cancer research & treatment
    Trial
  4. Article
  5. Article
  6. Article
  7. Association of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio with Persistent Allergic Rhinitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Treatment of obstructive sleep apnea with CPAP improves chronic inflammation measured by neutrophil-to-lymphocyte ratio.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  19. Pembrolizumab in Combination with the Oncolytic Virus Pelareorep and Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma: A Phase Ib Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  20. The association of allergic rhinitis severity with neutrophil-lymphocyte and platelet-lymphocyte ratio in adults.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuan GaoDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wen-Jie WangDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Qiaoming ZhiDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Meng ShenDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Min JiangDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiaojie BianDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Fei-Ran GongDepartment of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chong ZhouDepartment of Radiation Oncology, Xuzhou Central Hospital, Xuzhou, China.
Lian LianDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Meng-Yao WuDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jun FengDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Min TaoDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wei LiDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple cancers arise from sites of infection, chronic irritation, and inflammation. It has been widely accepted that pancreatic cancer is an inflammation-driven cancer. In this study, we investigated the application value of systemic inflammatory markers, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in the prediction of chemotherapy response and prognosis in patients with late pancreatic cancer. 122 patients with inoperable pancreatic cancers were included and separated into two groups according to median values of NLR or PLR (NLR low:<3.81 or NLR high:≥3.81, and PLR low:<142.14 or PLR high≥142.14, respectively). Baseline NLR and PLR levels were significantly higher in pancreatic cancer patients compared with the healthy subjects. Neither of the baseline NLR or PLR levels could predict outcomes. Patients with low baseline level of NLR, but not PLR, had better responses to chemotherapy. Changes in NLR, but not PLR levels, were associated with the therapeutic efficacy. Patients who stayed in or dropped into the low NLR level subgroup after first-line chemotherapy had better responses, comparing to those stayed in or jumped into the high NLR level group. No similar results could be observed when the PLR level was investigated. Therefore, NLR is a more sensitive biomarker than PLR in the prediction of chemotherapy response of patients.

Indexed as

neutrophil to lymphocyte ratio (NLR)pancreatic cancerplatelet to lymphocyte ratio (PLR)systemic inflammatory response (SIR)

Identifiers

PMID29179480
PMCPMC5687650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.