ArticleEnvironment international2018
Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Lifetime Swimming Pool Attendance and Cancer Risk: Findings from the Multicase-Control Study in Spain (MCC-Spain).Environmental science & technology · 2025Article
- Global research trends on the links between disinfection by-products and cancer: mapping knowledge landscapes and visualization analysis.Journal of water and health · 2025Review
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Effects of exposure to trihalomethanes in swimming pool waters on metabolomics profile: a randomized parallel design trial.Journal of environmental health science & engineering · 2024Article
- Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways.Environmental science & technology · 2024Article
- Metabolomic Signatures of Exposure to Nitrate and Trihalomethanes in Drinking Water and Colorectal Cancer Risk in a Spanish Multicentric Study (MCC-Spain).Environmental science & technology · 2023Article
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases.Human genomics · 2022Review
- [Occupational cancer of the urinary tract-incidence, reporting behavior, and administrative procedures].Urologie (Heidelberg, Germany) · 2022Review
- Identification of Potential Harmful Transformation Products of Selected Micropollutants in Outdoor and Indoor Swimming Pool Water.International journal of environmental research and public health · 2022Article
- Swimming and the human microbiome at the intersection of sports, clinical, and environmental sciences: A scoping review of the literature.Frontiers in microbiology · 2022Article
- Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer.Frontiers in oncology · 2022Review
- Data Processing Thresholds for Abundance and Sparsity and Missed Biological Insights in an Untargeted Chemical Analysis of Blood Specimens for Exposomics.Frontiers in public health · 2021Article
- The Occurrence ofEnvironmental health insights · 2021Review
- Human health risk estimation and predictive modeling of halogenated disinfection by- products (chloroform) in swimming pool waters: a case study of Dhanbad, Jharkhand, India.Journal of environmental health science & engineering · 2020Article
- Exposure to disinfection byproducts and risk of type 2 diabetes: a nested case-control study in the HUNT and Lifelines cohorts.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies.Environment international · 2019Article
- A multivariate approach to investigate the combined biological effects of multiple exposures.Journal of epidemiology and community health · 2018Article
- Modified APHA closed-tube reflux colorimetric method for TOC determination in water and wastewater.Environmental monitoring and assessment · 2018Article
- From John Snow to omics: the long journey of environmental epidemiology.European journal of epidemiology · 2018Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundExposure to disinfection by-products (DBPs) in drinking water and chlorinated swimming pools are associated with adverse health outcomes, but biological mechanisms remain poorly understood.
objectivesEvaluate short-term changes in metabolic profiles in response to DBP exposure while swimming in a chlorinated pool. MATERIALS AND
methodsThe PISCINA-II study (EXPOsOMICS project) includes 60 volunteers swimming 40min in an indoor pool. Levels of most common DBPs were measured in water and in exhaled breath before and after swimming. Blood samples, collected before and 2h after swimming, were used for metabolic profiling by liquid-chromatography coupled to high-resolution mass-spectrometry. Metabolome-wide association between DBP exposures and each metabolic feature was evaluated using multivariate normal (MVN) models. Sensitivity analyses and compound annotation were conducted.
resultsExposure levels of all DBPs in exhaled breath were higher after the experiment. A total of 6,471 metabolic features were detected and 293 features were associated with at least one DBP in exhaled breath following Bonferroni correction. A total of 333 metabolic features were associated to at least one DBP measured in water or urine. Uptake of DBPs and physical activity were strongly correlated and mutual adjustment reduced the number of statistically significant associations. From the 293 features, 20 could be identified corresponding to 13 metabolites including compounds in the tryptophan metabolism pathway.
conclusionOur study identified numerous molecular changes following a swim in a chlorinated pool. While we could not explicitly evaluate which experiment-related factors induced these associations, molecular characterization highlighted metabolic features associated with exposure changes during swimming.
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