SynthesisBMC veterinary research2017
Status of benzimidazole resistance in intestinal nematode populations of livestock in Brazil: a systematic review.
Synthesis in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Tannins Can Have Direct Interactions with Anthelmintics: Investigations by Isothermal Titration Calorimetry.Molecules (Basel, Switzerland) · 2023Article
- The Economic Impact of Parasitism from Nematodes, Trematodes and Ticks on Beef Cattle Production.Animals : an open access journal from MDPI · 2023Review
- The 22nd Chromatography Component of theAnimals : an open access journal from MDPI · 2023Article
- Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta.Environmental science and pollution research international · 2021Article
- Soybean (International journal of molecular sciences · 2021Article
- Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.The Korean journal of parasitology · 2021Review
- Maximising Societal Benefit From the Control of Neglected Zoonoses: Identifying Synergies and Trade-Offs in the Control ofFrontiers in veterinary science · 2021Review
- Article
- Teladorsagia circumcincta beta tubulin: the presence of the E198L polymorphism on its own is associated with benzimidazole resistance.Parasites & vectors · 2020Article
- The Identification of Metabolites and Effects of Albendazole in Alfalfa (International journal of molecular sciences · 2020Article
- The Uptake of Ivermectin and Its Effects in Roots, Leaves and Seeds of Soybean (Molecules (Basel, Switzerland) · 2020Article
- Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids.Chemical science · 2020Article
- Article
- Anthelmintic Activity of Extracts and Active Compounds FromFrontiers in veterinary science · 2020Article
- High Endemicity of Soil-Transmitted Helminths in a Population Frequently Exposed to Albendazole but No Evidence of Antiparasitic Resistance.Tropical medicine and infectious disease · 2019Article
- Albendazole and Praziquantel: Review and Safety Monitoring in Korea.Infection & chemotherapy · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBenzimidazoles (BZ) are a class of drugs widely used in veterinary and human medicine, creating a great selection pressure and the emergence of BZ resistance. We conducted a systematic review to assess the status of resistance and/or effectiveness reduction of BZ drugs in animal nematodes in Brazil, and make information accessible to the scientific community, as many studies are published in Portuguese. PubMed, SciELO Brasil, LILACS/Bireme, GNTD database, and Google Scholar were searched with no language restrictions.
resultsA total of 40 studies met our eligibility criteria (from the year 1989 forward). Sheep was the host most frequently analysed, and albendazole was the most frequently drug studied. The majority of studies (75.7%) showed that BZ drugs are insufficiently active (FECRT <80%) against nematode parasites of livestock. The mean FECRT for fenbendazole, thiabendazole, albendazole, mebendazole, oxfendazole, and ricobendazole were 71.8%, 71.8%, 58.6%, 53.9%, 46.9%, and 41.5%, respectively. It was observed through linear regression that FECRT is significantly reduced over time between 2007 and 2014 (R = -0.653 p = 0.021) for the treatment of cattle with BZ, suggesting progressive loss of effectiveness and increased resistance for these hosts.
conclusionsThe scenario of BZ resistance in nematode populations in Brazil is not favourable. Given the high cost of drug discovery and development, it is urgent to implement control measures and to monitor the effectiveness/resistance to nematodes in livestock in Brazil.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.