Evidence map›Paper›PMID 29178930›Full record

ArticleBMC research notes2017

An Msh3 ATPase domain mutation has no effect on MMR function.

Yasmin Edwards

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Yasmin EdwardsBronx Community College, 2155 University Avenue, Bronx, NY, 10453, USA. Yasmin.edwards@bcc.cuny.edu.ORCID http://orcid.org/0000-0001-9027-8724
Bronx Community College · US

Funding

DNA MISMATCH REPAIR AND CANCER IN MURINE MODELSR01CA076329 · NCI · YESHIVA UNIVERSITY · PI EDELMANN, WINFRIED · 1998 to 2017
$6.9M
The Role of Late MMR Proteins in DNA Repair and CancerR01CA093484 · NCI · YESHIVA UNIVERSITY · PI EDELMANN, WINFRIED · 2002 to 2011
$3.7M
National Institutes of Health ca93484National Institutes of Health (US) ca76329NCI NIH HHS R01 CA076329NCI NIH HHS R01 CA093484
6 · The paper itself

Abstract

objectiveTo demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model.

resultsThe DNA mismatch repair proteins are members of the ABC family of ATPases. ATP binding and hydrolysis regulates their mismatch repair function. In the current study, a mouse model was generated harboring a glycine to aspartic acid residue change in the Walker A motif of the ATPase domain of Msh3. Impaired ATP mediated release of the Msh2-Msh3

Indexed as

MutS DNA Mismatch-Binding ProteinMutS Homolog 3 ProteinProtein DomainsAnimalsDisease Models, AnimalHumansMiceMutationMsh3 protein, mouseMutS DNA Mismatch-Binding ProteinMutS Homolog 3 Protein

Identifiers

PMID29178930
PMCPMC5702223
OpenAlexW2769380930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.