ArticleBMC genomics2017
Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
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- Telomere-to-telomere genome assembly of Metarhizium acridum provides insights into Metarhizium genome evolution.BMC genomics · 2026Article
- Discovery of a fungal Tc toxin complex and functional mycoserpin through a novel two-by-two comparative genomics approach.Frontiers in cellular and infection microbiology · 2026Article
- Telomere-to-Telomere Assembly of theJournal of fungi (Basel, Switzerland) · 2025Article
- A Review of Genomic, Transcriptomic, and Proteomic Applications in Edible Fungi Biology: Current Status and Future Directions.Journal of fungi (Basel, Switzerland) · 2025Review
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- Biological characteristics of Cordyceps militaris single mating-type strains.Archives of microbiology · 2024Article
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- Genomic Sequence and Transcriptome Analysis of the Medicinal Fungus Keithomyces neogunnii.Genome biology and evolution · 2022Article
- Infection Process and Genome Assembly Provide Insights into the Pathogenic Mechanism of Destructive MycoparasiteJournal of fungi (Basel, Switzerland) · 2021Article
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- Cysteine-Rich Hydrophobin Gene Family: Genome Wide Analysis, Phylogeny and Transcript Profiling inInternational journal of molecular sciences · 2021Article
- Genome and Comparative Transcriptome Dissection Provide Insights Into Molecular Mechanisms of Sclerotium Formation in Culinary-Medicinal MushroomFrontiers in microbiology · 2021Article
- Secondary metabolites from hypocrealean entomopathogenic fungi: genomics as a tool to elucidate the encoded parvome.Natural product reports · 2020Review
- Dual-PKS Cluster for Biosynthesis of a Light-Induced Secondary Metabolite Found from Genome Sequencing of Hyphodiscus hymeniophilus Fungus.Chembiochem : a European journal of chemical biology · 2020Article
- Optimizing cultivation ofComputational and structural biotechnology journal · 2020Article
- Study of the whole genome, methylome and transcriptome of Cordyceps militaris.Scientific reports · 2019Article
- Whole Genome Sequence of an Edible and Potential Medicinal Fungus,G3 (Bethesda, Md.) · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCordyceps militaris is an insect pathogenic fungus that is prized for its use in traditional medicine. This and other entomopathogenic fungi are understudied sources for the discovery of new bioactive molecules. In this study, PacBio SMRT long read sequencing technology was used to sequence the genome of C. militaris with a focus on the genetic potential for secondary metabolite production in the genome assembly of this fungus.
resultsThis is first chromosome level assembly of a species in the Cordyceps genera. In this seven chromosome assembly of 33.6 Mba there were 9371 genes identified. Cordyceps militaris was determined to have the MAT 1-1-1 and MAT 1-1-2 mating type genes. Secondary metabolite analysis revealed the potential for at least 36 distinct metabolites from a variety of classes. Three of these gene clusters had homology with clusters producing desmethylbassianin, equisetin and emericellamide that had been studied in other fungi.
conclusionOur assembly and analysis has revealed that C. militaris has a wealth of gene clusters for secondary metabolite production distributed among seven chromosomes. The identification of these gene clusters will facilitate the future study and identification of the secondary metabolites produced by this entomopathogenic fungus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.