Evidence map›Paper›PMID 29178815›Full record

Trial reportRadiology2018

Central Core Laboratory versus Site Interpretation of Coronary CT Angiography: Agreement and Association with Cardiovascular Events in the PROMISE Trial.

Michael T Lu, Nandini M Meyersohn, Thomas Mayrhofer, Daniel O Bittner, Hamed Emami, Stefan B Puchner, Borek Foldyna, Martin E Mueller, Steven Hearne, Clifford Yang and 7 more

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Coronary artery and retinal vascularization by optical coherence tomography angiography: are eyes the window to the heart?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Usefulness of FFR-CT to exclude haemodynamically significant lesions in high-risk NSTE-ACS.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Computed tomographic angiography in coronary artery disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michael T LuFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Nandini M MeyersohnFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Thomas MayrhoferFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Daniel O BittnerFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Hamed EmamiFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Stefan B PuchnerFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Borek FoldynaFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Martin E MuellerFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Steven HearneFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Clifford YangFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Stephan AchenbachFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Quynh A TruongFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Brian B GhoshhajraFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Manesh R PatelFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Maros FerencikFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Pamela S DouglasFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).
Udo HoffmannFrom the Cardiac PET MR CT Program, Massachusetts General Hosp and Harvard Medical School, Boston, Mass (M.T.L., N.M.M., T.M., D.O.B., H.E., S.B.P., B.B.G., B.F., M.E.M., M.F., U.H.); School of Business Studies, Stralsund Univ of Applied Sciences, Stralsund, Germany (T.M.); Dept of Internal Medicine (Cardiology), Friedrich Alexander Univ Hosp, Erlangen, Germany (D.O.B., S.A.); Dept of Angiography and Interventional Radiology, Medical Univ Vienna, Vienna, Austria (S.B.P.); Delmarva Health LLC, Salisbury, Md (S.H.); Dept of Radiology, Univ of Connecticut Health Ctr, Farmington, Conn (C.Y.); Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College, New York, NY (Q.A.T.); Duke Clinical Research Inst, Duke Univ School of Medicine, Durham, NC (M.R.P., P.S.D.); and Knight Cardiovascular Inst, Oregon Health & Science Univ, Portland, Ore (M.F.).

Funding

PROMISE Trial: Clinical Coordinating CenterR01HL098237 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN · 2009 to 2014
$27.3M
PROMISE Trial: SDCCR01HL098236 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2009 to 2014
$5.0M
Cardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9M
PROMISE Trial: Dx CoreR01HL098305 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2009 to 2014
$3.5M
PROMISE Trial: EQOL Coordinating CenterR01HL098235 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2009 to 2014
$1.6M
Cardiovascular Imaging in Ischemic Heart DiseaseK24HL113128 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2012 to 2020
$1.1M
NHLBI NIH HHS K24 HL113128NHLBI NIH HHS R01 HL098235NHLBI NIH HHS R01 HL098236NHLBI NIH HHS R01 HL098237NHLBI NIH HHS R01 HL098305NHLBI NIH HHS T32 HL076136
6 · The paper itself

Abstract

Purpose To assess concordance and relative prognostic utility between central core laboratory and local site interpretation for significant coronary artery disease (CAD) and cardiovascular events. Materials and Methods In the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial, readers at 193 North American sites interpreted coronary computed tomographic (CT) angiography as part of the clinical evaluation of stable chest pain. Readers at a central core laboratory also interpreted CT angiography blinded to clinical data, site interpretation, and outcomes. Significant CAD was defined as stenosis greater than or equal to 50%; cardiovascular events were defined as a composite of cardiovascular death or myocardial infarction. Results In 4347 patients (51.8% women; mean age ± standard deviation, 60.4 years ± 8.2), core laboratory and site interpretations were discordant in 16% (683 of 4347), most commonly because of a finding of significant CAD by site but not by core laboratory interpretation (80%, 544 of 683). Overall, core laboratory interpretation resulted in 41% fewer patients being reported as having significant CAD (14%, 595 of 4347 vs 23%, 1000 of 4347; P < .001). Over a median follow-up period of 25 months, 1.3% (57 of 4347) sustained myocardial infarction or cardiovascular death. The C statistic for future myocardial infarction or cardiovascular death was 0.61 (95% confidence interval [CI]: 0.54, 0.68) for the core laboratory and 0.63 (95% CI: 0.56, 0.70) for the sites. Conclusion Compared with interpretation by readers at 193 North American sites, standardized core laboratory interpretation classified 41% fewer patients as having significant CAD.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseFemaleHumansMaleMiddle AgedProspective StudiesRetrospective Studies

Identifiers

PMID29178815
PMCPMC5881637

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