Evidence map›Paper›PMID 29178789›Full record

ArticleACS nano2017

Chelator-Free Labeling of Metal Oxide Nanostructures with Zirconium-89 for Positron Emission Tomography Imaging.

Liang Cheng, Sida Shen, Dawei Jiang, Qiutong Jin, Paul A Ellison, Emily B Ehlerding, Shreya Goel, Guosheng Song, Peng Huang, Todd E Barnhart and 2 more

Abstract read
In one paragraph

Article in ACS nano, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 42 citations in OpenAlex.

  1. Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  6. Nanomaterial Probes for Nuclear Imaging.Nanomaterials (Basel, Switzerland) · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Recent Advances in Zirconium-89 Chelator Development.Molecules (Basel, Switzerland) · 2018
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, Jiangsu 215123, China.ORCID 0000-0001-5324-9094
Sida ShenInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, Jiangsu 215123, China.
Dawei JiangDepartments of Radiology and Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Qiutong JinInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, Jiangsu 215123, China.
Paul A EllisonDepartments of Radiology and Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.ORCID 0000-0002-8379-7419
Emily B EhlerdingDepartments of Radiology and Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Shreya GoelDepartments of Radiology and Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Guosheng SongInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, Jiangsu 215123, China.
Peng HuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University , Shenzhen 518060, China.ORCID 0000-0003-3651-7813
Todd E BarnhartDepartments of Radiology and Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Zhuang LiuInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, Jiangsu 215123, China.ORCID 0000-0002-1629-1039
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.ORCID 0000-0003-4641-0833
University of Wisconsin–Madison · USSoochow University · CNShenzhen University · CN

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneityR01CA205101 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2016 to 2020
$1.9M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS R01 CA205101NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB021336NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Radiolabeling of molecules or nanoparticles to form imaging probes is critical for positron emission tomography (PET) imaging, which, with high sensitivity and the ability for quantitative imaging, has been widely used in the clinic. While conventional radiolabeling often employs chelator molecules, a general method for chelator-free radiolabeling of a wide range of materials remains to be developed. Herein, we determined that 10 different types of metal oxide (M

Indexed as

Positron-Emission TomographyChelating AgentsMagnetic Resonance ImagingMetals, HeavyMultimodal ImagingNanostructuresOxidesPolyethylene GlycolsChelating AgentsMetals, HeavyOxidesPolyethylene Glycols89Zrchelator-free labelinglabeling stabilitylymph node PET imagingmetal oxide nanomaterials

Identifiers

PMID29178789
PMCPMC5752591
OpenAlexW2769163799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.