Evidence map›Paper›PMID 29178697›Full record

ArticleJournal of biomedical optics2017

Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid.

Zhongdi Chu, Chieh-Li Chen, Qinqin Zhang, Kathryn Pepple, Mary Durbin, Giovanni Gregori, Ruikang K Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. The Impact of Carotid Endarterectomy on Choriocapillaris Perfusion.Investigative ophthalmology & visual science · 2023
    Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Adaptive optics imaging of the human retina.Progress in retinal and eye research · 2019
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhongdi ChuUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Chieh-Li ChenUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Qinqin ZhangUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Kathryn PeppleUniversity of Washington, Department of Ophthalmology, Seattle, Washington, United States.
Mary DurbinCarl Zeiss Meditec, Inc., Advanced Development, Dublin, California, United States.
Giovanni GregoriUniversity of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Department of Ophthalmol, United States.
Ruikang K WangUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
University of Washington · USCarl Zeiss (United States) · USUniversity of Miami · US

Funding

NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
The role of the innate and adaptive immune system in a novel model of uveitK08EY023998 · NEI · UNIVERSITY OF WASHINGTON · PI PEPPLE, KATHRYN · 2014 to 2018
$1.1M
NEI NIH HHS K08 EY023998NEI NIH HHS R01 EY024158
6 · The paper itself

Abstract

The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT). We show that the complex signal-based OMAG was superior to both the phase and amplitude signal-based approaches in detailing the vascular lobules previously seen with histological analysis. With this improved ability to visualize the lobular vascular networks, it is possible to identify the feeding arterioles and draining venules around the lobules, which is important in understanding the role of the CC in the pathogenesis of ocular diseases. With built-in FastTrac™ and montage scanning capabilities, we also demonstrate wide-field SD-OCT angiograms of the CC with a field of view at 9×11  mm2.

Indexed as

Tomography, Optical CoherenceAngiographyChoroidComputersFluorescein AngiographyHumanschoriocapillarishuman choroidoptical coherence tomographyoptical coherence tomography angiography

Identifiers

PMID29178697
PMCPMC5745879
OpenAlexW2769924066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.