Trial reportThe Journal of clinical psychiatry
A Supervised Exercise Intervention for Youth at Risk for Psychosis: An Open-Label Pilot Study.
Trial report in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02155699 (Exercise and Markers of Medial Temporal Health in Youth at Ultra High-risk for Psychosis), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise and Markers of Medial Temporal Health in Youth at Ultra High-risk for Psychosis
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Psychosocial and behavioural interventions for the negative symptoms of schizophrenia: a systematic review of efficacy meta-analyses.The British journal of psychiatry : the journal of mental science · 2023Pooled it
- Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study.Schizophrenia bulletin · 2024Trial
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.BJPsych open · 2025Article
- The Etiological Role of Impaired Neurogenesis in Schizophrenia: Interactions with Inflammatory, Microbiome and Hormonal Signaling.International journal of molecular sciences · 2025Review
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- Physical Health and Transition to Psychosis in People at Clinical High Risk.Biomedicines · 2024Article
- Physical and mental health in adolescence: novel insights from a transdiagnostic examination of FitBit data in the ABCD study.Translational psychiatry · 2024Article
- Physical and Mental Health in Adolescence: Novel Insights from a transdiagnostic examination of FitBit data in the ABCD Study.Research square · 2023Article
- The Effect of Physical Exercise on People with Psychosis: A Qualitative Critical Review of Neuroimaging Findings.Brain sciences · 2023Review
- Fitness is positively associated with hippocampal formation subfield volumes in schizophrenia: a multiparametric magnetic resonance imaging study.Translational psychiatry · 2022Article
- Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.Scientific reports · 2021Observational
- Sensorimotor and Activity Psychosis-Risk (SMAP-R) Scale: An Exploration of Scale Structure With Replication and Validation.Schizophrenia bulletin · 2021Article
- The impact of inflammation on neurocognition and risk for psychosis: a critical review.European archives of psychiatry and clinical neuroscience · 2020Review
- Using exercise to protect physical and mental health in youth at risk for psychosis.Research in psychotherapy (Milano) · 2020Article
- Advances in clinical staging, early intervention, and the prevention of psychosis.F1000Research · 2019Review
- What prevents youth at clinical high risk for psychosis from engaging in physical activity? An examination of the barriers to physical activity.Schizophrenia research · 2018Article
- Hippocampal Subregions Across the Psychosis Spectrum.Schizophrenia bulletin · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveA rapidly accumulating body of research suggests that exercise can improve symptoms and well-being in patients suffering from psychosis. Exercise may also promote neurogenesis in the hippocampus, a structure that plays an important role in the pathophysiology of psychosis. To date, there has not been an intervention focused on exercise prior to the onset of psychosis, a critical time for prevention of more serious illness.
methodsIn this pilot study, 12 young adults at ultrahigh risk (UHR) for psychosis were enrolled in a 12-week open-label exercise intervention. Participants were randomly assigned to exercise 2 or 3 times each week and exercised between 65% and 85% of maximum oxygen capacity (Vo2max) for 30 minutes each session under the supervision of an exercise physiologist. Positive and negative symptoms, social and role functioning, performance on neurocognitive tests, cardiovascular fitness, and hippocampal structure and functional connectivity were evaluated before and after the trial.
resultsA total of 9 participants completed the exercise intervention. Participants showed improved positive and negative symptoms and social and role functioning; improvement in multiple areas of cognition; and increased functional connectivity between the left hippocampus and occipital cortex after 12 weeks of exercise.
conclusionsThe results of this study suggest that exercise interventions are feasible in a UHR sample and may promote improvement in clinical, social, and cognitive domains as well as changes to brain function in regions impacted by the development of psychosis. These findings set the stage for an ongoing phase 2 randomized controlled trial.
trial registrationClinicalTrials.gov identifier: NCT02155699.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.