Trial reportObesity (Silver Spring, Md.)2018
Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial.
Trial report in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pooled it
- Prescription of therapeutic exercise in migraine, an evidence-based clinical practice guideline.The journal of headache and pain · 2023Guideline
- Healthy Eating Index Diet Quality in Randomized Weight Loss Trials: A Systematic Review.Journal of the Academy of Nutrition and Dietetics · 2023Pooled it
- Pooled it
- Effects of Surgical and Non-surgical Weight Loss on Migraine Headache: a Systematic Review and Meta-Analysis.Obesity surgery · 2020Pooled it
- The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis.The journal of headache and pain · 2019Pooled it
- Trial
- Exercise in a natural environment increases program compliance in people with chronic migraine: A pilot cross-over randomized trial.Journal of bodywork and movement therapies · 2024Trial
- Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020Trial
- The Association of Changes in Pain Acceptance and Headache-Related Disability.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Migraine and Obesity: From Shared Mechanisms to Therapeutic Strategies.Neurology and therapy · 2026Review
- Short-Term Changes in Migraine Burden After Roux-en-Y Gastric Bypass: A Prospective Cohort Study.Obesity surgery · 2026Article
- Integrating Nutrition and Physical Activity into the EXEMIG/01 Interdisciplinary Model for Chronic and High-Frequency Migraine.Nutrients · 2026Article
- Impact of bariatric surgery on headache frequency and severity and quality of life in patients with migraine: a prospective study.BMJ neurology open · 2026Article
- Nutrition and Physical Activity in an Interdisciplinary Approach to Migraine: A Narrative Review.Nutrients · 2025Review
- Acceptability of a Combined Aerobic Exercise and Sleep Intervention for Sedentary Individuals with Migraine.International journal of behavioral medicine · 2025Article
- Association of Migraine and Blood Pressure-Does Obesity Severity Have a Moderating Role?International journal of behavioral medicine · 2025Article
- Behavioral therapy in migraine: Expanding the therapeutic arsenal.European journal of neurology · 2024Review
- Incorporating Therapeutic Education and Exercise in Migraine Management: A Biobehavioral Approach.Journal of clinical medicine · 2024Review
- Advances in Exercise in the Clinical Trials of Migraine: A Scoping Review.Current pain and headache reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe objective of this study was to test whether behavioral weight loss (BWL) intervention decreases headaches in women with comorbid migraine and overweight or obesity.
methodsThis randomized, single-blind trial allocated women 18 to 50 years old with 4 to 20 migraine days per month and a BMI = 25.0-49.9 kg/m
resultsOf 110 participants randomly assigned, 85 (78%) and 80 (73%) completed posttreatment and follow-up. Although the BWL group achieved greater weight loss (mean [95% CI] in kilograms) than the ME group at posttreatment (-3.8 [-2.5 to -5.0] vs. + 0.9 [-0.4 to 2.2], P < 0.001) and follow-up (-3.2 [-2.0 to -4.5] vs. + 1.1 [-0.2 to 2.4], P < 0.001), there were no significant group (BWL vs. ME) differences (mean [95% CI]) in migraine days per month at posttreatment (-3.0 [-2.0 to -4.0] vs. -4.0 [-2.9 to -5.0], P = 0.185) or follow-up (-3.8 [-2.7 to -4.8] vs. -4.4 [-3.4 to -5.5], P = 0.378).
conclusionsContrary to hypotheses, BWL and ME yielded similar, sustained reductions in migraine headaches. Future research should evaluate whether adding BWL to standard pharmacological and/or nonpharmacological migraine treatment approaches yields greater benefits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.