ArticleObesity (Silver Spring, Md.)2018
A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality.
Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Does Metabolic Status Associate With IVF Outcomes in Women Within Similar Body Mass Index Category: Evidence From a Large Cohort Study.Journal of diabetes · 2025Article
- The Role of BMI in Allostatic Load and Risk of Cancer Death.American journal of preventive medicine · 2023Article
- Metabolic syndrome and the risk of severe cancer events: a longitudinal study in Japanese workers.BMC cancer · 2023Article
- Association of racial residential segregation with all-cause and cancer-specific mortality in the reasons for geographic and racial differences in stroke (REGARDS) cohort study.SSM - population health · 2023Article
- Obesity, the Adipose Organ and Cancer in Humans: Association or Causation?Biomedicines · 2023Review
- Serum Antioxidant Vitamins Mediate the Association between Periodontitis and Metabolically Unhealthy Overweight/Obesity.Nutrients · 2022Article
- Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Associations between obesity, metabolic syndrome, and endometrial cancer risk in East Asian women.Journal of gynecologic oncology · 2022Article
- Article
- Metabolomics Based onFoods (Basel, Switzerland) · 2021Article
- Review
- Systemic alterations play a dominant role in epigenetic predisposition to breast cancer in offspring of obese fathers and is transmitted to a second generation.Scientific reports · 2021Article
- Body roundness index is a superior indicator to associate with the cardio-metabolic risk: evidence from a cross-sectional study with 17,000 Eastern-China adults.BMC cardiovascular disorders · 2021Article
- Obesity and the Bidirectional Risk of Cancer and Cardiovascular Diseases in African Americans: Disparity vs. Ancestry.Frontiers in cardiovascular medicine · 2021Review
- The Role of Diet in Cancer Prevention and Chemotherapy Efficacy.Annual review of nutrition · 2020Review
- All-cause mortality in metabolically healthy individuals was not predicted by overweight and obesity.JCI insight · 2020Article
- Association of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults.JAMA oncology · 2020Article
- Association of Allostatic Load with All-Cause andCancer Mortality by Race and Body Mass Index in theREGARDS Cohort.Cancers · 2020Article
- Physical health composite and risk of cancer mortality in the REasons for Geographic and Racial Differences in Stroke Study.Preventive medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveThis study examined whether metabolic health status is associated with risk of cancer mortality and whether this varies by body mass index (BMI) category.
methodsA prospective study of 22,514 participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was performed. Metabolically unhealthy status was defined as having three or more of the following: (1) elevated fasting glucose, (2) high triglycerides, (3) dyslipidemia, (4) hypertension, and (5) elevated waist circumference. Participants were categorized into normal weight (BMI 18.5-24.9 kg/m
resultsAmong participants with normal weight, participants who were metabolically unhealthy had an increased risk of cancer mortality (HR: 1.65; 95% CI: 1.20-2.26) compared with metabolically healthy participants. The overall mortality risk for participants who were metabolically unhealthy and had normal weight was stronger for obesity-related cancers (HR: 2.40; 95% CI: 1.17-4.91). Compared with participants with normal weight, those who were metabolically healthy and overweight were at a reduced risk of any cancer mortality (adjusted HR: 0.79; 95% CI: 0.63-0.99).
conclusionsThere was an increased risk of overall and obesity-related cancer mortality among metabolically unhealthy participants with normal weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.