Evidence map›Paper›PMID 29178545›Full record

ArticleObesity (Silver Spring, Md.)2018

Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans.

Chuan Gao, Carl D Langefeld, Julie T Ziegler, Kent D Taylor, Jill M Norris, Yii-Der I Chen, Jacklyn N Hellwege, Xiuqing Guo, Matthew A Allison, Elizabeth K Speliotes and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. American journal of physiology. Endocrinology and metabolism · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The effects ofFASEB bioAdvances · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Gene-Environment Interactions on Body Fat Distribution.International journal of molecular sciences · 2019
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Chuan GaoMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Carl D LangefeldCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Julie T ZieglerCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Jacklyn N HellwegeCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Matthew A AllisonDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
Elizabeth K SpeliotesDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Donald W BowdenCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Lynne E WagenknechtDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Nicholette D PalmerCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-8883-2511
North Carolina Division of Public Health · USThe Lundquist Institute · USWake Forest University · USColorado School of Public Health · USUniversity of California San Diego · USUniversity of Michigan · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Genetic & Epidemiologic Predictors of Glucose Homeostasis Measures in HispanicsR01DK085175 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E, WATANABE, RICHARD M · 2010 to 2013
$6.9M
MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANSR01DK053591 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOWDEN, DONALD W · 1998 to 2015
$5.6M
IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCER01HL060944 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 1999 to 2009
$5.5M
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African AmericansR01HG007112 · NHGRI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOWDEN, DONALD W, LANGEFELD, CARL D · 2012 to 2016
$4.8M
Human population based genetic studies to elucidate the biology of NAFLDR01DK107904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2016 to 2020
$3.4M
Identification and functional impact of NAFLD associated genetic variantsR01DK106621 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2015 to 2019
$3.3M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS R01 HG007112NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061019NHLBI NIH HHS R01 HL067974NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01 HL088457NIDDK NIH HHS K99 DK081350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R00 DK081350NIDDK NIH HHS R01 DK053591NIDDK NIH HHS R01 DK085175NIDDK NIH HHS R01 DK087914NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904NIDDK NIH HHS R21 DK097524
6 · The paper itself

Abstract

objectiveThis study aimed to explore the genetic mechanisms of regional fat deposition, which is a strong risk factor for metabolic diseases beyond total adiposity.

methodsA genome-wide association study of 7,757,139 single-nucleotide polymorphisms (SNPs) in 983 Mexican Americans (n

resultsThe strongest signal identified was SNP rs2185405 (minor allele frequencies [MAF] = 40%; P

conclusionsSix loci were identified with genome-wide significant associations with fat deposition and interactive effects. These results provided genetic evidence for a differential basis of fat deposition between genders.

Indexed as

Adipose TissueAdiposityBody Mass IndexFemaleGenome-Wide Association StudyGenotypeHumansMaleMexican AmericansMiddle AgedObesityPhenotypePolymorphism, Single NucleotideRisk Factors

Identifiers

PMID29178545
PMCPMC5740005
OpenAlexW2768698438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.