Evidence map›Paper›PMID 29178418›Full record

ArticleJournal of neurochemistry2018

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.

Natalia Dominguez, Jan R T van Weering, Ricardo Borges, Ruud F G Toonen, Matthijs Verhage

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  6. Action potential-independent spontaneous microdomain CaProceedings of the National Academy of Sciences of the United States of America · 2025
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  15. In Vivo Imaging of Axonal Organelle Transport in the Mouse Brain.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  16. Article
  17. Measurement of Exocytosis in Genetically Manipulated Mast Cells.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Natalia DominguezDepartment of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and VU University Medical Center (VUmc), Amsterdam, The Netherlands.ORCID 0000-0002-2615-3414
Jan R T van WeeringDepartment of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and VU University Medical Center (VUmc), Amsterdam, The Netherlands.ORCID 0000-0001-5259-4945
Ricardo BorgesUnidad de Farmacología, Facultad de Medicina, Universidad de la Laguna, Tenerife, Spain.ORCID 0000-0003-3413-4392
Ruud F G ToonenFunctional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and VU University Medical Center (VUmc), Amsterdam, The Netherlands.ORCID 0000-0002-9900-4233
Matthijs VerhageDepartment of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and VU University Medical Center (VUmc), Amsterdam, The Netherlands.ORCID 0000-0002-6085-7503
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLUniversidad de La Laguna · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromogranin A and B (Cgs) are considered to be master regulators of cargo sorting for the regulated secretory pathway (RSP) and dense-core vesicle (DCV) biogenesis. To test this, we analyzed the release of neuropeptide Y (NPY)-pHluorin, a live RSP reporter, and the distribution, number, and appearance of DCVs, in mouse hippocampal neurons lacking expression of CHGA and CHGB genes. qRT-PCR analysis showed that expression of other granin family members was not significantly altered in CgA/B

Indexed as

ExocytosisOrganelle BiogenesisAnimalsChromogranin AChromogranin BFemaleHippocampusMaleMice, Inbred C57BLMice, KnockoutNeuronsPrimary Cell CultureSecretory VesiclesSynapsesChromogranin Achromogranin A, mouseChromogranin Bchromogranin B, mouseexocytosislive-cell imagingneuromodulationneuropeptidesneurotransmissionsecretion

Identifiers

PMID29178418
PMCPMC5814729
OpenAlexW2768503224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.