SynthesisOrthopaedic surgery2017
Effect of Intra-wound Vancomycin for Spinal Surgery: A Systematic Review and Meta-analysis.
Synthesis in Orthopaedic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04825522 (The Effect of Intrawound Vancomycin Powder in Spine Surgery), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Intrawound Vancomycin Powder in Spine Surgery: A Prospective Randomized Controlled Trial
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Local antibiotics in primary hip and knee arthroplasty: a systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Pooled it
- Local vancomycin therapy to reduce surgical site infection in adult spine surgery: a randomized prospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Trial
- Serum and local vancomycin concentrations following intrawound application in elective lumbar spinal fusion: A secondary pharmacokinetic analysis of the vancomycin arm of a prospective randomized controlled trial.North American Spine Society journal · 2026Article
- The Role of Intrawound Vancomycin Powder in Reducing Surgical Site Infections in Orthopedic Surgery: A Comprehensive Narrative Review of Its Efficacy, Safety, and Applications.Indian journal of orthopaedics · 2025Review
- Article
- Triple Encapsulation and Controlled Release of Vancomycin, Rifampicin and Silver from Poly (Methyl Methacrylate) or Poly (Lactic-Co-Glycolic Acid) Nanofibers.Bioengineering (Basel, Switzerland) · 2024Article
- Intra-articular Vancomycin Reduces Prosthetic Infection in Primary Hip and Knee Arthroplasty.Arthroplasty today · 2024Article
- The use of intra-articular vancomycin is safe in primary hip and knee arthroplasty.Journal of orthopaedics · 2023Article
- Implementing an infection control checklist May not be effective in reducing the incidence of surgical site infections in spinal surgery.Journal of infection prevention · 2022Article
- Risk Factors for Acute Surgical Site Infection after Spinal Instrumentation Procedures: A Case-Control Study.International journal of spine surgery · 2021Article
- Vancomycin bone and tissue concentrations following tibial intraosseous administration - evaluated in a porcine model.Journal of bone and joint infection · 2021Article
- [Low-grade-infections after spondylodeses-A chameleon? : Current findings and therapeutic strategies].Der Orthopade · 2020Review
- Intrawound vancomycin powder increases post-operative wound complications and does not decrease periprosthetic joint infection in primary total and unicompartmental knee arthroplasties.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- CORR Insights®: Chlorhexidine Antiseptic Irrigation Eradicates Staphylococcus epidermidis From Biofilm: An In Vitro Study.Clinical orthopaedics and related research · 2018Article
- Postoperative Surgical Site Infections in Spine Surgery: Can the Duration of Surgery Predict the Pathogen Spectrum?In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intra-site prophylactic vancomycin in spine surgery is an effective method of decreasing the incidence of postsurgical wound infection. However, there are differences in the prophylactic programs used for various spinal surgeries. Thus, this systematic review and meta-analysis aimed to evaluate the effectiveness of using intra-wound vancomycin during spinal surgery and to explore the effects of dose-dependence and the method of administration in a subgroup analysis. A total of 628 citations or studies were searched in PubMed, Ovid, Web of Science, and Google Scholar that were published before August 2016 with the terms "local vancomycin", "intra-wound vancomycin", "intraoperative vancomycin", "intra-site vancomycin", "topical vancomycin", "spine surgery", and "spinal surgery". Finally, 19 retrospective cohort studies and one prospective case study were eligible for inclusion in the systematic review and meta-analysis. The odds of developing postsurgical wound infection without prophylactic local vancomycin use were 2.83-fold higher than the odds of experiencing wound infection with the use of intra-wound vancomycin (95% confidence interval, 2.03-3.95; P = 0.083; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.