Evidence map›Paper›PMID 29178137›Full record

ArticleProteins2018

Continuous Automated Model EvaluatiOn (CAMEO) complementing the critical assessment of structure prediction in CASP12.

Jürgen Haas, Alessandro Barbato, Dario Behringer, Gabriel Studer, Steven Roth, Martino Bertoni, Khaled Mostaguir, Rafal Gumienny, Torsten Schwede

Abstract read
In one paragraph

Article in Proteins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
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  9. Review
  10. Article
  11. Article
  12. Article
  13. Plants (Basel, Switzerland) · 2025
    Article
  14. The Need for Continuing Blinded Pose- and Activity Prediction Benchmarks.Journal of chemical information and modeling · 2025
    Review
  15. Review
  16. Article
  17. Recent advances and challenges in protein complex model accuracy estimation.Computational and structural biotechnology journal · 2024
    Review
  18. Article
  19. Article
  20. AI-Driven Deep Learning Techniques in Protein Structure Prediction.International journal of molecular sciences · 2024
    Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jürgen HaasBiozentrum, University of Basel, Switzerland.ORCID 0000-0002-3255-7773
Alessandro BarbatoBiozentrum, University of Basel, Switzerland.
Dario BehringerBiozentrum, University of Basel, Switzerland.
Gabriel StuderBiozentrum, University of Basel, Switzerland.
Steven RothBiozentrum, University of Basel, Switzerland.
Martino BertoniBiozentrum, University of Basel, Switzerland.
Khaled MostaguirBiozentrum, University of Basel, Switzerland.
Rafal GumiennyBiozentrum, University of Basel, Switzerland.
Torsten SchwedeBiozentrum, University of Basel, Switzerland.

Funding

The Protein Structure Inittiative KnowledgebaseU01GM093324 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI BERMAN, HELEN M · 2010 to 2015
$12.9M
NIGMS NIH HHS U01 GM093324
6 · The paper itself

Abstract

Every second year, the community experiment "Critical Assessment of Techniques for Structure Prediction" (CASP) is conducting an independent blind assessment of structure prediction methods, providing a framework for comparing the performance of different approaches and discussing the latest developments in the field. Yet, developers of automated computational modeling methods clearly benefit from more frequent evaluations based on larger sets of data. The "Continuous Automated Model EvaluatiOn (CAMEO)" platform complements the CASP experiment by conducting fully automated blind prediction assessments based on the weekly pre-release of sequences of those structures, which are going to be published in the next release of the PDB Protein Data Bank. CAMEO publishes weekly benchmarking results based on models collected during a 4-day prediction window, on average assessing ca. 100 targets during a time frame of 5 weeks. CAMEO benchmarking data is generated consistently for all participating methods at the same point in time, enabling developers to benchmark and cross-validate their method's performance, and directly refer to the benchmarking results in publications. In order to facilitate server development and promote shorter release cycles, CAMEO sends weekly email with submission statistics and low performance warnings. Many participants of CASP have successfully employed CAMEO when preparing their methods for upcoming community experiments. CAMEO offers a variety of scores to allow benchmarking diverse aspects of structure prediction methods. By introducing new scoring schemes, CAMEO facilitates new development in areas of active research, for example, modeling quaternary structure, complexes, or ligand binding sites.

Indexed as

Models, MolecularProtein ConformationBinding SitesComputational BiologyDatabases, ProteinHumansLigandsProtein BindingProteinsSequence Analysis, ProteinLigandsProteinsbenchmarkingCAMEOCASPcontinuous evaluationligand binding site accuracymodel confidencemodel quality assessmentoligomeric assessmentprotein structure modelingprotein structure prediction

Identifiers

PMID29178137
PMCPMC5820194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.