ArticleMetabolic brain disease2018
Administration of Allium cepa L. bulb attenuates stress-produced anxiety and depression and improves memory in male mice.
Article in Metabolic brain disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
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- Effects of ultrasound-induced stress on gut microbiota of mice.Veterinary world · 2023Article
- Inhibitory Effects of Selenium on Arsenic-Induced Anxiety-/Depression-Like Behavior and Memory Impairment.Biological trace element research · 2022Article
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- The effects ofIranian journal of basic medical sciences · 2021Review
- Pharmacological Properties ofIranian journal of pharmaceutical research : IJPR · 2021Review
- Effects of onion extract containing concentrated cysteine sulfoxides on sleep quality: a randomized, double-blind, placebo-controlled, crossover study.Food science and biotechnology · 2020Article
- Behavioral and Biochemical Effects ofMedicina (Kaunas, Lithuania) · 2020Article
- Protective effect of gallic acid against arsenic-induced anxiety-/depression- like behaviors and memory impairment in male rats.Metabolic brain disease · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In view of anxiolytic, antidepressant and memory strengthen properties of Allium cepa (AC; onion) bulb in various investigations; we aimed to evaluate the useful effects of onion on single immobilization stress -induced biochemical and behavioral changes. Mice in test group were treated with AC powder (200 mg/kg/day), dissolved in water, while the control group were received drinking water for 14 days. After 14 days control and AC treated mice were further divided into unstressed and stressed groups. Animals in the stressed group were subjected to immobilization stress for 2 h. 24-h after the immobilization stress, behavioral activities were monitored. Immobilization stress-induced an anxiogenic behavior in mice subjected to elevated plus maze test (EPM) and light dark activity test (LDA). 2-h immobilization stress-induced depressive behavior in animals measured by forced swim test (FST). Administration of AC attenuated the immobilization stress-induced behavioral deficits. Highest memory performance was observed in stressed mice that were pre-treated with AC in Morris water maze (MWM). Brain lipid peroxidation, antioxidant enzymes (SOD, CAT, GPx) and acetylcholinesterase (AChE) activities were also estimated. Present study suggests a role of antioxidant enzymes in the attenuation of 2-h stress induced anxiety and depression, and enhanced cognitive function as well by AC. The findings therefore suggest that supplementation of AC may be beneficial in the treatment of anxiety, depression and enhancement of memory function.
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