ArticleClinical pharmacokinetics2018
Correction to: Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.
Article in Clinical pharmacokinetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Systemic opioid regimens for postoperative pain in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Systemic opioid regimens for postoperative pain in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study.Drug design, development and therapy · 2026Trial
- Effects of sufentanil combined with remifentanil on hemodynamics during induction and postoperative recovery quality in preschool children undergoing tonsillectomy and adenoidectomy.BMC anesthesiology · 2025Trial
- Dexmededomidine in pediatric unilateral internal inguinal ring ligation.World journal of clinical cases · 2022Trial
- Population Pharmacokinetics of Alfentanil in Children.Journal of clinical pharmacology · 2025Article
- Opioids and alpha-2-agonists for analgesia and sedation in newborn infants: protocol of a systematic review.Systematic reviews · 2020Article
- Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis.Journal of clinical pharmacology · 2020Article
- Procedural pain management in neonates: A Narrative review.International journal of critical illness and injury scienceReview
Corrections and comments
- Erratum for
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A comprehensive review of the use of fentanyl and its derivatives in the pediatric population was performed using the National Library of Medicine PubMed. Studies were included if they contained original pharmacokinetic parameters or models using established routes of administration in patients younger than 18 years of age. Of 372 retrieved articles, 44 eligible pharmacokinetic studies contained data of 821 patients younger than 18 years of age, including more than 46 preterm infants, 64 full-term neonates, 115 infants/toddlers, 188 children, and 28 adolescents. Underlying diagnoses included congenital heart and pulmonary disease and abdominal disorders. Routes of drug administration were intravenous, epidural, oral-transmucosal, intranasal, and transdermal. Despite extensive use in daily clinical practice, few studies have been performed. Preterm and term infants have lower clearance and protein binding. Pharmacokinetics was not altered by chronic renal or hepatic disease. Analyses of the pooled individual patients' data revealed that clearance maturation relating to body weight could be best described by the Hill function for sufentanil (R
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.