ArticleAMB Express2017
Production of poly-γ-glutamic acid by a thermotolerant glutamate-independent strain and comparative analysis of the glutamate dependent difference.
Article in AMB Express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Coculture Corynebacterium glutamicum and Bacillus licheniformis for producing poly-γ-glutamic acid from glucose.Applied microbiology and biotechnology · 2025Article
- Production and Characterization of Poly-γ-Glutamic Acid byMicroorganisms · 2025Article
- Article
- Effective Decolorization of Poly-γ-Glutamic Acid Fermentation Broth by Integrated Activated Carbon Adsorption and Isoelectric Point Precipitation of Glutamic Acid.Molecules (Basel, Switzerland) · 2024Article
- Investigation of γ-polyglutamic acid production via asynchronous saccharification and fermentation of raw corn starch.World journal of microbiology & biotechnology · 2024Article
- Genomic characterization and related functional genes of γ- poly glutamic acid producing Bacillus subtilis.BMC microbiology · 2024Article
- Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability.Frontiers in microbiology · 2024Review
- Synthesis of Poly-γ-Glutamic Acid and Its Application in Biomedical Materials.Materials (Basel, Switzerland) · 2023Review
- Poly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization.Biomass conversion and biorefinery · 2023Review
- Recent Advances in Microbial Synthesis of Poly-γ-Glutamic Acid: A Review.Foods (Basel, Switzerland) · 2022Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Poly-γ-glutamic acid (γ-PGA) is a promising microbial polymer with wide applications in industry, agriculture and medicine. In this study, a novel glutamate-independent γ-PGA producing strain with thermotolerant characteristics was isolated and identified as Bacillus subtilis GXG-5, then its product was also characterized. The fermentation process was optimized by single-factor tests, and results showed that high temperature (50 °C) was especially suitable for the γ-PGA production by GXG-5. The γ-PGA yield reached 19.50 ± 0.75 g/L with substrate conversion efficiency of 78% at 50 °C in 10 L fermentor. Comparison of GXG-5 and GXA-28 (glutamate-dependent strain) under respective optimal fermentation conditions, the γ-PGA yield of GXG-5 was 19.0% higher than that of GXA-28, and GXG-5 was also superior to GXA-28 in the availability of carbon sources and substrates. Furthermore, the glutamate dependent difference between GXA-28 and GXG-5 was analyzed by genomic sequencing, results indicated that genes related to the glutamate dependent difference mainly involved in carbohydrate transport and metabolism and amino acid metabolism, and 13 genes related to γ-PGA synthesis were mutated in GXG-5. This study provided a potential glutamate-independent strain to replace glutamate-dependent strain for γ-PGA production, and shared novel information for understanding the glutamate dependent difference at the genomic level.
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