Evidence map›Paper›PMID 29177796›Full record

ReviewStem cell reviews and reports2018

Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases.

Bojana Simovic Markovic, Tatjana Kanjevac, C Randall Harrell, Marina Gazdic, Crissy Fellabaum, Nebojsa Arsenijevic, Vladislav Volarevic

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bojana Simovic MarkovicFaculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Serbia, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia.
Tatjana KanjevacFaculty of Medical Sciences, Department of Dentistry, University of Kragujevac, Serbia, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia.
C Randall HarrellRegenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL, USA.
Marina GazdicFaculty of Medical Sciences, Department of Genetics, University of Kragujevac, Serbia, Kragujevac, Serbia.
Crissy FellabaumRegenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL, USA.
Nebojsa ArsenijevicFaculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Serbia, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia.
Vladislav VolarevicFaculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Serbia, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia. vladislav.volarevic@ana.unibe.ch.ORCID 0000-0002-0510-7822
University of Kragujevac · RS

Funding

Faculty of Medical Sciences University of Kragujevac JP02/09Serbian Ministry of Science ON175069, ON175103
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are promising resource for the therapy of inflammatory bowel diseases (IBDs) on the grounds of their differentiation capabilities and immuno-modulatory characteristics. Results of clinical studies indicate that local application of MSCs is a secure and beneficial approach for the treatment of perianal fistulas while systemic application of MSCs leads to the attenuation or aggravation of IBDs. Herein, we emphasized molecular mechanisms and approaches that should improve efficacy of MSC-based therapy of IBDs.

Indexed as

AnimalsCell- and Tissue-Based TherapyHumansInflammatory Bowel DiseasesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationCell-based therapyChron’s diseaseMesenchymal stem cellsTransplantationUlcerative colitis

Identifiers

PMID29177796
OpenAlexW2770118279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.