Evidence map›Paper›PMID 29177686›Full record

ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2018

Preclinical animal study of the NIPRO-ventricular assist device for use in pediatric patients.

Noritsugu Naito, Yoshiaki Takewa, Satoru Kishimoto, Kei Iizuka, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Noritsugu NaitoDepartment of Cardiothoracic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyoku, Tokyo, Japan. nori.naito@gmail.com.
Yoshiaki TakewaDepartment of Artificial Organs, National Cerebral and Cardiovascular Center, Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, Japan.
Satoru KishimotoDepartment of Artificial Organs, National Cerebral and Cardiovascular Center, Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, Japan.
Kei IizukaDepartment of Artificial Organs, National Cerebral and Cardiovascular Center, Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, Japan.
Toshihide MizunoDepartment of Artificial Organs, National Cerebral and Cardiovascular Center, Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, Japan.
Tomonori TsukiyaDepartment of Artificial Organs, National Cerebral and Cardiovascular Center, Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, Japan.
Minoru OnoDepartment of Cardiothoracic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyoku, Tokyo, Japan.
Eisuke TatsumiDepartment of Artificial Organs, National Cerebral and Cardiovascular Center, Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, Japan. tatsumi@ncvc.go.jp.
National Cerebral and Cardiovascular Center · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the outcomes of patients with end-stage heart failure treated with implantable left ventricular assist devices have improved, extracorporeal left ventricular assist devices continue to play an important role, especially in pediatric patients. The present study aimed to examine the long-term biocompatibility of a small-sized extracorporeal pneumatic left ventricular assist device (NIPRO-LVAD) used in a 30- to 90-day animal experiment. The NIPRO-LVAD was designed for pediatric patients or small-sized adults. The left ventricular assist device system was installed in four adult Shiba goats weighing 25.7 ± 4.78 kg via a left thoracotomy. The outflow graft was sewn to the descending aorta and the inflow cannula was placed in the left ventricle through the left ventricular apex. Oral antiplatelet (aspirin) and oral anticoagulation therapies (warfarin) were also administered. Three out of four animals survived for a 30-day period and two goats survived for 90 days. One animal was killed early because of low pump flow due to obstruction of the inflow cannula by a left ventricular endocardial vegetation. The blood pump exhibited sufficient hydrodynamic performance with blood flows of 1.5-2.0 L/min. The animals' laboratory values were within normal limits by postoperative day 7. There was no significant thrombus formation on the housing, diaphragm, or valves of the explanted pumps. Based on the biocompatibility demonstrated in this animal study, the explanted small-sized pump may be suitable for use in left ventricular assist device systems for pediatric patients.

Indexed as

Heart-Assist DevicesAnimalsChildGoatsHeart VentriclesHumansHydrodynamicsMaterials TestingProsthesis ImplantationThrombosisLeft ventricular assist devicePediatric cardiothoracic surgeryThrombosis

Identifiers

PMID29177686
OpenAlexW2770871787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.