Evidence map›Paper›PMID 29177676›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018

Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review.

Ashish H Shah, Ziad Khatib, Toba Niazi

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Timing of radiotherapy and autologous stem cell transplantation in embryonal tumor with multilayered rosettes: a critical narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. ETMR: a tumor entity in its infancy.Acta neuropathologica · 2020
    Review
  7. Embryonal tumor with multilayered rosettes: illustrative case and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashish H ShahDivision of Pediatric Neurological Surgery, Miami Children's Hospital and University of Miami Miller School of Medicine, 3215 SW 62nd Avenue, Ambulatory Care Building, Suite 3109, Miami, FL, 33155, USA. ashah@med.miami.edu.
Ziad KhatibDivision of Hematology/Oncology, Department of Pediatrics, Miami Children's Hospital and Florida International University, Herbert Wertheim College of Medicine, Miami, FL, 33155, USA.
Toba NiaziDivision of Pediatric Neurological Surgery, Miami Children's Hospital and University of Miami Miller School of Medicine, 3215 SW 62nd Avenue, Ambulatory Care Building, Suite 3109, Miami, FL, 33155, USA. toba.niazi@mch.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmbryonal tumors with multilayered rosettes (ETMR) is a rare variant of embryonal tumor of infancy with nearly 200 cases reported in the literature. Leptomeningeal spread of this tumor is well known; however, extracranial metastasis has been sparsely reported in the literature.

methodsOur study was divided into two sections: (1) We conducted a retrospective review of our patient series of ETMR and screened for patients with evidence of ETMR over the last 10 years 2007-2017 at a single tertiary referral pediatric hospital, and (2) we conducted a systematic review according to PRISMA guidelines of all reported cases of ETMR to determine the incidence of extracranial metastasis and treatment paradigms.

resultsHere we report three cases of extracranial non-CNS spread of ETMR and conduct a systematic review of ETMR to improve our understanding of ETMR metastases and treatment paradigms. In our systematic review (n = 204), median overall survival was less than 1 year with 44.1% children surviving over 1 year. Previously, only five cases of extracranial metastasis of ETMR have been reported.

conclusionsOur case series (n = 3) and review demonstrate that these tumors may behave like soft tissue sarcomas and may be susceptible to tumor seeding through surgical manipulation or by CSF (ventriculoperitoneal shunt). Surgery for tumor recurrence may offer an improved local disease control, but preventative measures such as meticulous surgical resection may be necessary to reduce intraoperative contamination.

Indexed as

Central Nervous System NeoplasmsNeoplasms, Germ Cell and EmbryonalNeuroectodermal Tumors, PrimitiveChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingMaleRetrospective StudiesEmbryonal tumorsExtracranialMultilayered rosettes

Identifiers

PMID29177676

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.