ArticleJournal of experimental orthopaedics2017
The use of lumbar epidural injection of platelet lysate for treatment of radicular pain.
Article in Journal of experimental orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing the Efficacy of Transforaminal Epidural Injections, Acupuncture and Platelet Rich Plasma Injection in Patients With Sciatica Due to Intervertebral Disc Herniation, Spinal Stenosis and Spondylolisthesis
Autologous Nebulized Platelet Lysate for Post COVID-19 Syndrome
"Platelet-Rich Plasma" Transforaminal Epidural Injection an Emerging Strategy in Lumbar Disc Herniation
A Trial of Platelet Injections for Treatment of Painful Degenerative Disc Disease
Single-Blind, Randomized, Controlled, Crossover Study of Autologous Platelet Lysate Versus Saline in Adults With Lumbosacral Radiculopathy
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Epidural Regenerative Medicine Therapies in Managing Spinal Pain.Current pain and headache reports · 2026Pooled it
- Therapeutic interventions of platelet-rich plasma versus corticosteroid injections for lumbar radicular pain: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- The clinical efficacy of percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis.Frontiers in surgery · 2025Pooled it
- Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials.Experimental biology and medicine (Maywood, N.J.) · 2025Pooled it
- Non-surgical treatment of anterior cruciate ligament tears with percutaneous bone marrow concentrate and platelet products versus exercise therapy: a randomized-controlled, crossover trial with 2-year follow-up.BMC musculoskeletal disorders · 2025Trial
- "Platelet-Rich Plasma" epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial.BMC musculoskeletal disorders · 2023Trial
- Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study.Neural plasticity · 2021Trial
- Article
- Stem cell therapy for degenerative disc disease: A systematic review of preclinical evidence, clinical translation, and future directions.North American Spine Society journal · 2026Review
- Safety and Efficacy of Autologous Bone-Marrow-Derived Mesenchymal Stem Cells for Treating Partial Rotator Cuff Tears: Observational Study with 4-Year Follow-Up.Biomedicines · 2026Article
- A novel platelet-rich plasma clinically induces reliable, rapid, long-term chronic peripheral neuropathic pain elimination.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Long-Term Effectiveness of Intradiscal Culture-Expanded Mesenchymal Stem Cells (MSCs) with Platelet Products for Discogenic Low Back Pain.Biomedicines · 2025Article
- Article
- Ulnar Neuropathy Hydrodissection With Platelet Lysate and Prolotherapy: A Case Series and Review of the Literature.Cureus · 2025Article
- Clinically Reducing/Eliminating Chronic Neuropathic Pain by Bridging Peripheral Nerve Gaps with an Autograft within a PRP-Filled Collagen Tube.Journal of pain research · 2025Article
- Mechanisms for reducing/eliminating chronic neuropathic pain with a focus on platelet-rich plasma.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Current Review of Regenerative Medicine Therapies for Spine-Related Pain.Current pain and headache reports · 2024Review
- Article
- An evaluation of the effectiveness of platelet rich plasma epidural injections for low back pain suspected to be of disc origin - A pilot study with one-year follow-up.Interventional pain medicine · 2024Article
- Injections of Platelet-Rich Plasma: An Emerging Novel Biological Cure for Low Back Pain?Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficacy is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet lysate (PL) epidural injections for the treatment of lumbar radicular pain as an alternative to corticosteroids.
methodsRegistry data was obtained for patients (N = 470) treated with PL epidural injections presenting with symptoms of lumbar radicular pain and MRI findings that were consistent with symptoms. Collected outcomes included numeric pain score (NPS), functional rating index (FRI), and a modified single assessment numeric evaluation (SANE) rating.
resultsPatients treated with PL epidurals reported significantly lower (p < .0001) NPS and FRI change scores at all time points compared to baseline. Post-treatment FRI change score means exceeded the minimal clinically important difference beyond 1 month. Average modified SANE ratings showed 49.7% improvement at 24 months post-treatment. Twenty-nine (6.3%) patients reported mild adverse events related to treatment.
conclusionPatients treated with PL epidurals reported significant improvements in pain, exceeded the minimal clinically important difference (MCID) for FRI, and reported subjective improvement through 2-year follow-up. PL may be a promising substitute for corticosteroid.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.