Evidence map›Paper›PMID 29177593›Full record

GuidelineArchives of gynecology and obstetrics2018

Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part I: Indications for fertility preservation.

A N Schüring, T Fehm, K Behringer, M Goeckenjan, P Wimberger, M Henes, J Henes, M F Fey, M von Wolff

Open access · hybridAbstract readGuideline
In one paragraph

Guideline in Archives of gynecology and obstetrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Guideline
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  8. Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age-Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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  18. Fertility preservation in hematological cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

A N SchüringUKM Kinderwunschzentrum, Department of Gynaecology and Obstetrics, University Hospital of Münster, Albert-Schweitzer Campus 1, D-11, 48149, Münster, Germany. Andreas.Schuering@ukmuenster.de.
T FehmDepartment of Gynaecology and Obstetrics, University Hospital of Düsseldorf, Düsseldorf, Germany.
K BehringerDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
M GoeckenjanDepartment of Gynaecology and Obstetrics, TU Dresden, Dresden, Germany.
P WimbergerDepartment of Gynaecology and Obstetrics, TU Dresden, Dresden, Germany.
M HenesDepartment of Women's Health, University of Tübingen, Tübingen, Germany.
J HenesCentre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmology), University of Tübingen, Tübingen, Germany.
M F FeyDepartment of Medical Oncology, Inselspital and University of Berne, Berne, Switzerland.
M von WolffDivision of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Berne, Switzerland.
TU Dresden · DEUniversity of Tübingen · DEDüsseldorf University Hospital · DEUniversity Children’s Hospital Bern · CHUniversity Hospital Cologne · DEUniversity Hospital Münster · DEUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost guidelines about fertility preservation are predominantly focused on scientific evidence, but are less practically orientated. Therefore, practically oriented recommendations are needed to support the clinician in daily practice.

methodsA selective literature search was performed based on the clinical and scientific experience of the authors, focussing on the most relevant diseases and gynaecological cancers. This article (Part I) provides information on topics that are essential for the fertility preservation indication, such as disease prognosis, disease therapy and its associated risks to fertility, recommending disease-specific fertility preservation measures. Part II specifically focusses on fertility preservation techniques.

resultsIn breast cancer patients, fertility preservation such as ovarian tissue and oocyte cryopreservation is especially recommended in low-stage cancer and in women < 35 years of age. In Hodgkin's lymphoma, the indication is mainly based on the chemotherapy regime as some therapies have very low, others very high gonadotoxicity. In borderline ovarian tumours, preservation of fertility usually is achieved through fertility sparing surgery, ovarian stimulation may also be considered. In cervical cancer, endometrial cancer, rheumatic diseases and other malignancies such as Ewing sarcoma, colorectal carcinoma, non-Hodgkin lymphoma, leukaemia etc., several other factors must be considered to enable an individual, stage-dependent decision.

conclusionThe decision for or against fertility preservation depends on the prognosis, the risks to fertility and individual factors such as prospective family planning.

Indexed as

AdultFemaleFertility PreservationHumansOvulation InductionProspective StudiesYoung AdultBorderline ovarian tumourBreast cancerCervical cancerFertility preservationHodgkin’s lymphomaRheumatic diseases

Identifiers

PMID29177593
PMCPMC5762797
OpenAlexW2769732820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.