Evidence map›Paper›PMID 29177135›Full record

ArticleFrontiers in cellular and infection microbiology2017

Quorum Sensing Down-Regulation Counteracts the Negative Impact of

Émilie Maillé, Manon Ruffin, Damien Adam, Hatem Messaoud, Shantelle L Lafayette, Geoffrey McKay, Dao Nguyen, Emmanuelle Brochiero

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Deleterious effect ofERJ open research · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Pathophysiology of Lung Disease and Wound Repair in Cystic Fibrosis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Dismantling the bacterial virulence program.Microbial biotechnology · 2019
    Article
  14. Repair Process Impairment byFrontiers in cellular and infection microbiology · 2019
    Review
  15. Article
  16. Frontiers in immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Émilie MailléCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Manon RuffinCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Damien AdamCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Hatem MessaoudCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Shantelle L LafayetteMeakins-Christie Laboratories at the Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Geoffrey McKayMeakins-Christie Laboratories at the Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Dao NguyenMeakins-Christie Laboratories at the Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Emmanuelle BrochieroCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Centre Hospitalier de l’Université de Montréal · CAMcGill University Health Centre · CAUniversité de Montréal · CA

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
CIHR PJT148593NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

The function of cystic fibrosis transmembrane conductance regulator (CFTR) channels is crucial in human airways. However unfortunately, chronic

Indexed as

Down-RegulationAminopyridinesBacterial ProteinsBenzodioxolesCell LineCells, CulturedChildCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsGene Expression Regulation, BacterialHumansInfantMutationPiperazinesPseudomonas aeruginosa4-cyclohexyloxy-2-(1-(4-(4-methoxy-benzenesulfonyl)piperazin-1-yl)ethyl)quinazolineAminopyridinesBacterial ProteinsBenzodioxolesCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorLasR protein, Pseudomonas aeruginosalumacaftorPiperazinesQuinazolinesTrans-ActivatorsCFTRcorrectorscystic fibrosisfuranoneinfectionLasRP. aeruginosaVx-809

Identifiers

PMID29177135
PMCPMC5686086
OpenAlexW2767385434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.