Evidence map›Paper›PMID 29177085›Full record

ArticleConvergent science physical oncology2017

Sucrose modulation of radiofrequency-induced heating rates and cell death.

Merlyn Pulikkathara, Colette Mark, Natasha Kumar, Ana Maria Zaske, Rita E Serda

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Convergent science physical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Merlyn PulikkatharaMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA (location where research was performed).
Colette MarkMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA (location where research was performed).
Natasha KumarMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA (location where research was performed).
Ana Maria ZaskeIM Bioscope 2 UT Core Facility, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Rita E SerdaMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA (location where research was performed).
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · US

Funding

TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2009 to 2014
$10.8M
Cytochrome P450C24 Regulation in Prostate CancerF31CA106197 · NCI · UNIVERSITY OF NEW MEXICO · PI SERDA, RITA ELENA · 2004 to 2006
$76k
NCI NIH HHS U54 CA143837
6 · The paper itself

Abstract

backgroundApplied radiofrequency (RF) energy induces hyperthermia in tissues, facilitating vascular perfusion This study explores the impact of RF radiation on the integrity of the luminal endothelium, and then predominately explores the impact of altering the conductivity of biologically-relevant solutions on RF-induced heating rates and cell death. The ability of cells to survive high sucrose (i.e. hyperosmotic conditions) to achieve lower conductivity as a mechanism for directing hyperthermia is evaluated.

methodsRF radiation was generated using a capacitively-coupled radiofrequency system operating at 13.56 MHz. Temperatures were recorded using a FLIR SC 6000 infrared camera.

resultsRF radiation reduced cell-to-cell connections among endothelial cells and altered cell morphology towards a more rounded appearance at temperatures reported to cause

conclusionsSucrose is known to form weak hydrogen bonds in fluids as opposed to ions, freeing water molecules to rotate in an oscillating field of electromagnetic radiation and contributing to heat induction. The ability of cells to survive temporal exposures to hyperosmotic (i.e. elevated sucrose) conditions creates an opportunity to use sucrose or other saccharides to selectively elevate heating in specific tissues upon exposure to a radiofrequency field.

Indexed as

cancerconductivityhyperthermiaradiofrequencyserumsucrose

Identifiers

PMID29177085
PMCPMC5697764
OpenAlexW2618062807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.