ArticleBMJ open gastroenterology2017
Validity of studies suggesting postsurgical chemotherapy for resectable gastric cancer: critical appraisal of randomised trials.
Article in BMJ open gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lentivirus-Mediated Overexpression of SIVA-1 Reverses Cisplatin Resistance in Gastric Cancer in vitro.Cell biochemistry and biophysics · 2020Article
- Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany.World journal of gastrointestinal oncology · 2020Article
- Adjuvant chemotherapy in curatively resected rectal cancer: How valid are the data?World journal of gastrointestinal oncology · 2020Article
- Validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer: A critical appraisal of randomized trials.World journal of gastrointestinal oncology · 2020Article
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3 authors.
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Abstract
BACKGROUND AND
aimIn 2013, Diaz-Nieto
methodsOverall survival was selected as endpoint of interest. Among the 34 included papers which analysed this endpoint, we identified the four publications which have the highest weights to influence the final result. The validity of these papers was analysed using the CONSORT (Consolidated Standards of Reporting Trials) checklist for randomised controlled trials. We performed a new meta-analysis without the four studies in order to assess their impact on the general result of the original meta-analysis.
resultsThe analysed four studies revealed several inconsistencies: inappropriate answers were found in up to 77% of the items of the CONSORT checklist. Unclear or inadequate randomisation, missing blinded set-up, conflict of interest and lacking intention-to-treat analysis were the most common findings. When performing a meta-analysis excluding the four criticised studies, postsurgical chemotherapy still showed a significant improvement in overall survival. Even when excluding all single studies with a statistically significant outcome by themselves and performing a meta-analysis on the remaining 26 studies, the result remains statistically significant.
conclusionThe four most powerful publications in the Cochrane review show substantial deficits. We suggest a more critical appraisal regarding the validity of single studies. However, after the exclusion of these four studies, the result of the meta-analysis did not change.
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