Evidence map›Paper›PMID 29177020›Full record

ArticleClinical epigenetics2017

Epigenetic regulation of

Lu Gao, Joshua Millstein, Kimberly D Siegmund, Louis Dubeau, Rachel Maguire, Frank D Gilliland, Susan K Murphy, Cathrine Hoyo, Carrie V Breton

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Neonatal Lead (Pb) Exposure and DNA Methylation Profiles in Dried Bloodspots.International journal of environmental research and public health · 2020
    Article
  8. Article
  9. Review
  10. Epigenetics in Asthma.Current allergy and asthma reports · 2019
    Review
  11. Article
  12. Article
  13. Role of epigenetics in the development of childhood asthma.Current opinion in allergy and clinical immunology · 2018
    Review
  14. Association betweenEpigenetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lu GaoDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA 90032 USA.
Joshua MillsteinDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA 90032 USA.
Kimberly D SiegmundDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA 90032 USA.
Louis DubeauDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA 90032 USA.
Rachel MaguireDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695 USA.
Frank D GillilandDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA 90032 USA.
Susan K MurphyDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27710 USA.
Cathrine HoyoDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695 USA.
Carrie V BretonDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA 90032 USA.
Keck Hospital of USC · USNorth Carolina State University · USDuke University · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Prenatal Tobacco Smoke, Genetic and Epigenetic Changes, and Respiratory HealthR01ES022216 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2013 to 2016
$2.0M
Prenatal air pollution, DNA methylation and early signs of atherosclerosisK01ES017801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2010 to 2014
$652k
NIEHS NIH HHS K01 ES017801NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES022216
6 · The paper itself

Abstract

Background: Methods: We investigated the association between Results: Higher average methylation of CpGs in the Conclusions:

Indexed as

DNA MethylationAsthmaAxl Receptor Tyrosine KinaseChildComputer SimulationCpG IslandsEpigenesis, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic Association StudiesGenetic Predisposition to DiseaseHumansLogistic ModelsMaleProto-Oncogene ProteinsAXL protein, humanAxl Receptor Tyrosine KinaseProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesChildrenEpigeneticsMethylation

Identifiers

PMID29177020
PMCPMC5688797
OpenAlexW2767735095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.