ArticlePlant methods2017
A cautionary note on the use of chromosome conformation capture in plants.
Article in Plant methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A fine-scale Arabidopsis chromatin landscape reveals chromatin conformation-associated transcriptional dynamics.Nature communications · 2024Article
- An upgraded method of high-throughput chromosome conformation capture (Hi-C 3.0) in cotton (Frontiers in plant science · 2023Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundThe chromosome conformation capture (3C) technique is a method to study chromatin interactions at specific genomic loci. Initially established for yeast the 3C technique has been adapted to plants in recent years in order to study chromatin interactions and their role in transcriptional gene regulation. As the plant scientific community continues to implement this technology, a discussion on critical controls, validations steps and interpretation of 3C data is essential to fully benefit from 3C in plants.
resultsHere we assess the reliability and robustness of the 3C technique for the detection of chromatin interactions in
conclusionsThe 3C technique offers an interesting opportunity to study chromatin interactions at a resolution infeasible by microscopy. However, for interpretation of 3C interaction data and identification of true interactions, 3C technology demands a stringent experimental setup and extreme caution.
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Registered trials
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